U.S.-Malaysia Cooperative Research: Bloom Dynamics and Physiology of the Toxic Red Tide Dinoflagellate Pyrodinium Bahamensa from Malaysia.

9224474 Anderson本申请申请资金，以允许波士顿大学伍兹霍尔海洋项目的博士生Gires Usup先生在伍兹霍尔海洋研究所的Donald M. Anderson博士的指导下，在马来西亚进行为期24个月的论文改进研究，研究有毒赤潮鞭毛藻（Pyrodinium bahamensa）的繁殖动力学和生理学。马来西亚沙巴西海岸有毒赤潮的反复爆发给该区域造成了严重的公共卫生和经济问题。目前正在对沙巴分离物的实验室培养进行生理和毒性研究。本研究是论文项目的实地组成部分，旨在了解沙巴西海岸赤潮爆发的动态。采样巡航和监测程序将用于定量表征这种有毒鞭毛藻的时空分布，其种群的运动以及在水华发展期间发生的生物事件。还将定量分析水华发生、水柱物理特性和气象条件之间的关系。有害或有毒的藻华在世界许多沿海地区变得越来越普遍。当致病的鞭毛藻是一种有毒物种时，悬浮液食性双壳类动物将强效的神经毒素集中在它们的组织中。食用这些贝类会导致麻痹性贝类中毒，这对人类，特别是儿童来说是致命的。安德森博士是红潮甲藻研究领域公认的权威。Usup先生从马来西亚Kebangsaan大学沙巴校区海洋科学系讲师的职位上休假，在这一领域也有研究出版物。Norhadi Ismail先生是马来西亚国民大学（Universiti Kebangsaan Malaysia）与Usup先生在这些研究中的合著者，他将在目前的研究中合作。该项目与东亚和太平洋项目的目标相关，该项目鼓励在东南亚等美国和外国调查人员之间的互动有限的地区提出活动建议。＊＊＊

9224474 Anderson This proposal requests funds to permit dissertation improvement research, in Malaysia, by Mr. Gires Usup, a Ph.D. student in the Boston University Marine Program, Woods Hole, MA, under the direction of Dr. Donald M. Anderson, Woods Hole Oceanographic Institution, within a 24-month period, on the bloom dynamics and physiology of the toxic red tide dinoflagellate Pyrodinium bahamensa. Recurring outbreaks of toxic red tides on the west coast of Sabah, Malaysia, have caused serious public health and economic problems in that region. Physiological and toxicity studies are currently underway on a laboratory culture of an isolate from Sabah. The present study is the field component of the dissertation project aimed at understanding the bloom dynamics of red tide outbreaks on the west coast of Sabah. Sampling cruises and monitoring programs will be used to quantitatively characterize the spatial and temporal distribution of this toxic dinoflagellate, the movement of its populations, and the biological events that take place during bloom development. The relationship between bloom occurrence, the physical characteristics of the water column, and meteorological conditions also will be quantitatively analyzed. Harmful or noxious algal blooms are becoming increasingly common in many coastal regions of the world. When the causative dinoflagellate is a toxic species, suspension-feeding bivalves concentrate the potent neurotoxins in their tissues. Consumption of these shellfish leads to paralytic shellfish poisoning which can be fatal to human beings, especially, children. Dr. Anderson is a recognized authority on red tide dinoflagellates. Mr. Usup, on leave from his position as Lecturer, Marine Sciences Department, University Kebangsaan Malaysia, Sabah Campus, also has research publications in this field. Mr. Norhadi Ismail, a co-author with Mr. Usup in these studies at Universiti Kebangsaan Malaysia, will collaborate in the present research. Th is project is relevant to the objectives of the East Asia and Pacific Program which encourages proposals for activities in regions such as Southeast Asia where interactions between U.S. and foreign investigators have been limited. ***