NSF Young Investigator

NSF 青年研究员

• 批准号: 9257856
• 负责人: John Henson
• 金额: $ 22.75万
• 依托单位: Dickinson College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9257856&HistoricalAwards=false
• 关键词: NSF; Young; Investigator

This is a National Science Foundation Young Investigator Award. The goal of Dr. Henson's laboratory is to investigate the molecular mechanism of cell shape changes and microfilament and microtubule based motility in an invertebrate blood cell (the coelomocyte). Cytoskeletal associated proteins will be isolated, characterized, and localized in the cells using light and electron microscopic immunocytochemical methods. The regulation of shape changes by calcium will also be addressed. %%% This is a National Science Foundation Young Investigator Award. Dr. Henson is interested in the fundamental and important question of how cells change their shapes. Cellular shape changes are critical to cellular functions (including movement) and organismal development. Dr. Henson is currently using sea urchin coelomocytes as models for studying shape changes associated with cellular motility. These cells are analogous to white blood cells of higher animals, and their ability to change shape is critical to the ability of sea urchins to defend themselves against microbial pathogens.

这是国家科学基金会青年研究者奖。 汉森博士实验室的目标是研究 细胞形态变化机制与微丝和微管 基于无脊椎动物血细胞（体腔细胞）的运动。 细胞骨架相关蛋白将被分离，表征， 并通过光镜和电子显微镜定位在细胞中 免疫细胞化学方法。 形状变化的规律是 还将讨论钙。 %%% 这是国家科学基金会青年研究者奖。 汉森博士对一个基本而重要的问题感兴趣 细胞是如何改变形状的 细胞形状的变化是 对细胞功能（包括运动）和生物体至关重要 发展 汉森博士目前正在使用海胆体腔细胞 作为研究与细胞相关的形状变化的模型 能动性 这些细胞类似于高血压患者的白色血细胞。 动物，他们改变形状的能力是至关重要的， 海胆抵御微生物的能力 病原体