NSF Young Investigator

NSF 青年研究员

• 批准号: 9258004
• 负责人: Jeffrey Chalmers
• 金额: $ 31.25万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9258004&HistoricalAwards=false
• 关键词: NSF; Young; Investigator

9258004 Chalmers Research activities are to be divided into three areas. The first of these is on: The effect of Fluid Dynamic Forces on Cells. A significant challenge in the large scale production of products from animal and insect cells is the prevention of cell damage from hydrodynamic forces. The knowledge generated by this research activity is to allow for the rational criteria for the design, operation, and scale-up of bioreactors. The second area is on: Bioremediation of Solid Organics. Initial research in this ares involves the application of chemical and biochemical engineering principals to evaluate processes for the biodegradation of wastes. The third area is on: Magnetically Facilitated Cell Separations. The ultimate goal of this research is to develop a continuous, magnetically-based cell sorter (CMCS) analogous to the fluorescence-based flow cytometer (FACS). The basis of the CMCS technique is the ability to label a unique immunological protein on the cell of interest with an antibody linked to a compound which is paramagnetic.

9258004 查尔默斯研究活动分为三个领域。 第一个是：流体动力对细胞的影响。 大规模生产动物和昆虫细胞产品的一个重大挑战是防止水动力造成的细胞损伤。 这项研究活动产生的知识将为生物反应器的设计、操作和放大提供合理的标准。 第二个领域是：固体有机物的生物修复。 该领域的初步研究涉及应用化学和生化工程原理来评估废物生物降解过程。 第三个领域是：磁促进细胞分离。 这项研究的最终目标是开发一种连续的、基于磁性的细胞分选仪（CMCS），类似于基于荧光的流式细胞仪（FACS）。 CMCS 技术的基础是能够用与顺磁性化合物连接的抗体在感兴趣的细胞上标记独特的免疫蛋白。