NSF Young Investigator

9258004 Chalmers研究活动将分为三个领域。第一个是流体动力对细胞的影响。从动物和昆虫细胞中大规模生产产品的一个重大挑战是防止水动力对细胞的损伤。这项研究活动所产生的知识将为生物反应器的设计、操作和规模扩大提供合理的标准。第二个领域是：固体有机物的生物修复。这方面的初步研究涉及应用化学和生物化学工程原理来评价废物的生物降解过程。第三个领域是：磁促进细胞分离。本研究的最终目标是开发一种类似于基于荧光的流式细胞仪（FACS）的连续的、基于磁的细胞分选器（CMCS）。CMCS技术的基础是能够用与顺磁性化合物相连的抗体在感兴趣的细胞上标记独特的免疫蛋白。

9258004 Chalmers Research activities are to be divided into three areas. The first of these is on: The effect of Fluid Dynamic Forces on Cells. A significant challenge in the large scale production of products from animal and insect cells is the prevention of cell damage from hydrodynamic forces. The knowledge generated by this research activity is to allow for the rational criteria for the design, operation, and scale-up of bioreactors. The second area is on: Bioremediation of Solid Organics. Initial research in this ares involves the application of chemical and biochemical engineering principals to evaluate processes for the biodegradation of wastes. The third area is on: Magnetically Facilitated Cell Separations. The ultimate goal of this research is to develop a continuous, magnetically-based cell sorter (CMCS) analogous to the fluorescence-based flow cytometer (FACS). The basis of the CMCS technique is the ability to label a unique immunological protein on the cell of interest with an antibody linked to a compound which is paramagnetic.