NSF Young Investigator
NSF Young Investigator
批准号:
9258004
负责人:
Jeffrey Chalmers
金额:
$31.25万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
1992
资助国家:
美国
项目状态:
已结题
起止时间:
1992-09-01 至 1998-08-31
关键词:
中文摘要
9258004查尔默斯的研究活动分为三个领域。 其中第一个是:流体动力对细胞的影响。 从动物和昆虫细胞大规模生产产品的一个重大挑战是防止流体动力造成的细胞损伤。 通过这项研究活动产生的知识是允许的设计,操作和放大生物反应器的合理标准。 第二个领域是:固体有机物的生物修复。 这一战神的初步研究包括应用化学和生物化学工程原理来评价废物的生物降解过程。 第三个领域是:磁促进细胞分离。 本研究的最终目标是开发一种类似于基于荧光的流式细胞仪(FACS)的连续的基于磁性的细胞分选仪(CMCS)。 CMCS技术的基础是能够用与顺磁性化合物连接的抗体标记感兴趣细胞上的独特免疫蛋白。
英文摘要
9258004 Chalmers Research activities are to be divided into three areas. The first of these is on: The effect of Fluid Dynamic Forces on Cells. A significant challenge in the large scale production of products from animal and insect cells is the prevention of cell damage from hydrodynamic forces. The knowledge generated by this research activity is to allow for the rational criteria for the design, operation, and scale-up of bioreactors. The second area is on: Bioremediation of Solid Organics. Initial research in this ares involves the application of chemical and biochemical engineering principals to evaluate processes for the biodegradation of wastes. The third area is on: Magnetically Facilitated Cell Separations. The ultimate goal of this research is to develop a continuous, magnetically-based cell sorter (CMCS) analogous to the fluorescence-based flow cytometer (FACS). The basis of the CMCS technique is the ability to label a unique immunological protein on the cell of interest with an antibody linked to a compound which is paramagnetic.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Collaborative Research: CCL1: Educational Materials to Enhance Chemical Engineering Curricula with Applications in Biological Engineering
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批准号:0816823
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项目类别:Standard Grant
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资助金额:$3.38万
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财政年份:2009
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负责人:Jeffrey Chalmers
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依托单位:
The Development of Theoretical and Experimental Characterizations of the Magnetophoretic Molbility of Immunomagnetically Labeled Cells
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批准号:0124897
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项目类别:Continuing Grant
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资助金额:$48.11万
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财政年份:2002
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负责人:Jeffrey Chalmers
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依托单位:
Determination of Cellular Properties Based on the Distribution of Cell Velocities Induced by External Fields
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批准号:9731059
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项目类别:Continuing Grant
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资助金额:$46.02万
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财政年份:1998
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负责人:Jeffrey Chalmers
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依托单位:
Determination of the Mechanisms of Cell Adhesion to and Damage from Air-Liquid Interfaces
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批准号:9109151
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项目类别:Standard Grant
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资助金额:$13.73万
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财政年份:1991
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负责人:Jeffrey Chalmers
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依托单位:
海外基金