RUI: Phospholipid Metabolism in Tissue Culture Cells and Tetrahymena

9304195 Smith本研究的目标是：1)利用激素诱导3T3-L1成纤维细胞分化为脂肪细胞，以检测不同磷脂头基在受体结构和功能中的作用；2)利用改变的磷脂组成来研究动物细胞中磷脂代谢的调节；3)继续发展纤毛虫原生动物嗜热四膜虫作为研究真核生物磷脂代谢以及不同磷脂在膜结构和功能中作用的模式系统。这项研究将让本科生参与对科学生涯有用的实验室经验。本研究的目的是检测合成的膜成分类似物对存在于细胞膜中的受体蛋白功能的影响，并利用这些化合物来研究细胞膜的磷脂组成及其在动物细胞中的调节。此外，研究人员还将继续开发纤毛原生动物作为模型系统，研究真核生物的磷脂代谢以及不同磷脂在膜结构和功能中的作用。这项研究将让本科生参与对科学生涯有用的实验室经验*

9304195 Smith The goals of this research are: 1) to use the hormone-induced differentiation of 3T3-L1 fibroblasts into adipocytes to examine the role of different phospholipid head-groups in receptor structure and function 2) to use altered Phospholipid composition to study regulation of phospholipid metabolism in animal cells and 3) to continue to develop the use of the ciliate protozoan Tetrahymena thermophila as a model system for the study of eukaryotic phospholipid metabolism and the role of different phospholipids in membrane structure and function. The research will involve undergraduates in laboratory experience useful for a scientific career. %%% The goals of this research are to examine the effect of synthetic analogs of membrane components on the function of receptor proteins which exist embedded within the cell membrane, and to use these compounds to study the phospholipid composition of cellular membranes and its regulation in animal cells. Also, the investigator will continue to develop the use of the ciliated protozoan as a model system for the study of eukaryotic phospholipid metabolism and the role of different phospholipids in membrane structure and function. The research will involve undergraduates in laboratory experience useful for a scientific career ***