How does heme regulate blood vessel formation in the brain?

血红素如何调节大脑中的血管形成？

• 批准号: DE230101536
• 负责人: Dr Rosemary Cater
• 金额: $ 33.39万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-12-31 至 2026-12-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101536
• 关键词: How; does; heme; regulate; blood

There are more than 600 kilometres of blood vessels in the brain, all of which are lined by tightly packed cells that protect the brain from toxins. My research aims to investigate how these blood vessels are formed. This project expects to reveal the role that a critical signalling molecule called heme plays in this fundamental biological process. I will use cutting-edge structural biology and biophysical techniques to uncover the molecular mechanisms that allow heme to enter cells and regulate blood vessel growth in the brain. The outcomes of this research will enhance our understanding of the brain’s core infrastructure and will contribute to an understanding of how cerebral blood vessels grow and maintain integrity.

大脑中有600多公里长的血管，所有这些血管都排列着紧密排列的细胞，保护大脑免受毒素的伤害。我的研究旨在调查这些血管是如何形成的。该项目希望揭示一种名为血红素的关键信号分子在这一基本生物过程中所起的作用。我将使用尖端的结构生物学和生物物理技术来揭示使血红素进入细胞并调节大脑中血管生长的分子机制。这项研究的结果将增强我们对大脑核心基础设施的了解，并将有助于了解脑血管如何生长和保持完整性。