Elucidating the molecular mechanisms of dual function transporter/channels

阐明双功能转运蛋白/通道的分子机制

• 批准号: FT220100717
• 负责人: Prof Renae Ryan
• 金额: $ 79.64万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100717
• 关键词: Elucidating; molecular; mechanisms; dual; function

This project aims to understand how a membrane protein that transports chemical messengers in the brain functions and how it is influenced by the membrane in which it is embedded. Cells from all life forms have a lipid membrane that separates them from their external environment. These membranes contain proteins that control the movements of molecules into and out of cells and are vital for a plethora of physiological processes including cell-to-cell communication. The outcomes of this study will include new knowledge of this process and chemical modifiers of this transport protein. This project will benefit structural biology and biophysics training and may lead to the development of novel compounds that can be used to explore function.

这个项目旨在了解在大脑中运输化学信使的膜蛋白是如何发挥作用的，以及它是如何受到嵌入其中的膜的影响的。所有生命形式的细胞都有一层脂膜，将它们与外部环境隔开。这些膜含有控制分子进出细胞的蛋白质，对包括细胞间通讯在内的大量生理过程至关重要。这项研究的结果将包括对这一过程的新知识和这种运输蛋白的化学修饰物。该项目将有助于结构生物学和生物物理学的培训，并可能导致可用于探索功能的新化合物的开发。