Biologically inert probes to unravel nutrient directed cellular processing

生物惰性探针揭示营养定向细胞加工

• 批准号: DP220103393
• 负责人: Prof Renae Ryan
• 金额: $ 40.27万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103393
• 关键词: Biologically; inert; probes; unravel; nutrient

In this project we will develop novel compounds that can act as probes of the pathways present in cells for the uptake of nutrients and other essential molecules and show how to generate new agents for identifying and targeting specific populations of cells. The project will generate new tools for understanding biological processes including cell transport and processing. The insights gained from this work are expected to help guide the development of new agents for selectively delivering imaging and biologically active agents to cells.

在这个项目中，我们将开发新型化合物，这些化合物可以作为细胞中存在的摄取营养物质和其他必需分子的途径的探针，并展示如何生成用于识别和靶向特定细胞群体的新试剂。该项目将产生新的工具来理解生物过程，包括细胞运输和加工。从这项工作中获得的见解预计将有助于指导新药物的开发，以选择性地将成像和生物活性药物递送到细胞中。