Vertebrate Renal Phosphate Transport

脊椎动物肾磷酸盐转运

• 批准号: 9306619
• 负责人: J. Larry Renfro
• 金额: $ 19.5万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-15 至 1998-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9306619&HistoricalAwards=false
• 关键词: Vertebrate; Renal; Phosphate; Transport

9306619 Renfro Inorganic phosphate is an important part of cells as well as body components such as bone. The amount of phosphate within an organism can alter bodily calcium balance, acidity of body fluids, and growth. Phosphate regulation is, therefore, important in all vertebrates. Dietary intake, intestinal absorption and renal excretion determine the body phosphate balance. The processes in the kidneys which control the excretion of phosphate are not understood in animals such as birds and fishes. Unlike mammals, the latter have a mechanism to transfer phosphate directly from blood to the urine through kidney cells. The objectives of this work include the study of the mechanism of phosphate transfer at both the cellular and cell membrane levels. Regulation of phosphate excretion by the kidneys involves the interaction of hormone, acid-base balance, and dietary phosphate availability. We will examine the basic cellular processes by which these factors alter body phosphate. ***

9306619伦弗罗无机磷酸盐是细胞的重要组成部分，也是骨骼等身体成分。生物体内的磷酸盐含量会改变人体的钙平衡、体液酸度和生长。因此，磷酸盐调节在所有脊椎动物中都很重要。饮食摄入量、肠道吸收和肾脏排泄决定了人体的磷酸盐平衡。在鸟类和鱼类等动物身上，肾脏中控制磷酸盐排泄的过程尚不清楚。与哺乳动物不同，后者有一种机制，可以通过肾脏细胞将磷酸盐直接从血液转移到尿液中。这项工作的目标包括研究磷酸盐在细胞膜和细胞膜水平上的转移机制。肾脏对磷酸盐排泄的调节涉及激素、酸碱平衡和膳食磷酸盐利用率的相互作用。我们将研究这些因素改变体内磷酸盐的基本细胞过程。***