Comparative Physiology of Renal Transepithelial Phosphate Transport in Three Vertebrate Systems

三种脊椎动物系统肾跨上皮磷酸盐转运的比较生理学

• 批准号: 9604070
• 负责人: J. Larry Renfro
• 金额: $ 23.44万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9604070&HistoricalAwards=false
• 关键词: Comparative; Physiology; Renal; Transepithelial; Phosphate

9604070 Renfro Inorganic phosphate has important functions in all cells and is a vital part of structural components of the body such as bones and teeth. The amount of phosphate within an organism can alter calcium balance, acidity of body fluids, and growth. Dietary phosphate intake and renal excretion determine the availability of inorganic phosphate for normal metabolism. Inadequate dietary phosphorous intake can cause hypophosphatemia, which, if chronic is a potentially deleterious state, especially in a growing animal. Hypophosphatemia is avoided by rapid mobilization of phosphate from muscle and bone. This can result in hypercalcemia and increased renal calcium excretion. Thus, the kidney mechanisms of transport as well as their control are important areas of investigation. Renal excretion of phosphate is regulated, or otherwise influenced, by a variety of factors including serum phosphate concentration, acid-base balance, and calcium metabolism as well as a variety of hormones. In the vertebrates, a multitude of hormones has been shown to alter renal phosphate transport, but our understanding of the control of this process is incomplete. Recently, both stanniocalcin and somotolactin, hormones which were thought to be unique to fish, have been found in other vertebrate classes including mammals (rats and humans). Because these hormones stimulate phosphate transport in flounder, it is important to examine their effect on phosphate transport in other vertebrates. Dr. Renfro will examine the processes by which these factors alter body phosphate.

小行星9604070 无机磷酸盐在所有细胞中具有重要功能，是身体结构组成部分（如骨骼和牙齿）的重要组成部分。 有机体中磷酸盐的量可以改变钙平衡，体液酸度和生长。 膳食磷酸盐摄入和肾脏排泄决定了正常代谢所需无机磷酸盐的有效性。 膳食磷摄入不足可导致低磷血症，如果慢性，这是一种潜在的有害状态，特别是在生长中的动物中。 低磷血症可通过快速动员肌肉和骨骼中的磷酸盐来避免。 这可导致高钙血症和肾钙排泄增加。 因此，肾脏转运机制及其控制是重要的研究领域。 磷酸盐的肾排泄受多种因素调节或影响，包括血清磷酸盐浓度、酸碱平衡和钙代谢以及多种激素。 在脊椎动物中，许多激素已被证明可以改变肾脏磷酸盐转运，但我们对这一过程的控制的理解是不完整的。 最近，斯钙素和生长抑素，被认为是鱼类特有的激素，已被发现在其他脊椎动物类，包括哺乳动物（大鼠和人类）。 由于这些激素刺激比目鱼的磷酸盐转运，因此研究它们对其他脊椎动物磷酸盐转运的影响很重要。 Renfro博士将研究这些因素改变体内磷酸盐的过程。