Factors that Effect Signal Transduction by Nuclear Receptors

影响核受体信号转导的因素

• 批准号: 9307388
• 负责人: Keith Yamamoto
• 金额: $ 37.5万
• 依托单位: University of California-San Francisco
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9307388&HistoricalAwards=false
• 关键词: Factors; Effect; Signal; Transduction; Nuclear

9307388 Yamamoto The glucocorticoid receptor is an intracellular factor that binds to a specific class of circulating hormonal steroids; this hormone-receptor interaction triggers binding of the receptor to specific stress on DNA and a subsequent change in the expression of nearby genes. Recent evidence suggests that in addition to the hormone, certain other factors also interact with the receptor and modify its activity; these include a heat shock protein, phosphate addicts, and DNA itself. Dr. Yamamoto proposes that these other interacting species may also convey signaling information to the receptor, and that the receptor consequently serves to integrate signals from different regulatory input pathways. He will investigate the nature and consequences of these various receptor-ligand interactions, using a range of molecular, genetic, biochemical and structural approaches. As signal transduction processes are universal and fundamental for communication within and between cells, a better understanding of the glucocorticoid receptor signaling pathway, and of the mechanisms by which multiple signaling inputs may converge on a single factor, could be generally significant for analyses of many transactions of biological information. ***

小行星9307388 糖皮质激素受体是一种细胞内因子，与特定类型的循环激素类固醇结合;这种糖皮质激素-受体相互作用触发受体与DNA上的特定应激结合，并随后改变附近基因的表达。 最近的证据表明，除了激素，某些其他因素也与受体相互作用并改变其活性;这些因素包括热休克蛋白，磷酸盐成瘾者和DNA本身。 Yamamoto博士提出，这些其他相互作用的物种也可能向受体传递信号信息，因此受体可以整合来自不同调节输入途径的信号。 他将研究这些不同的受体-配体相互作用的性质和后果，使用一系列的分子，遗传，生物化学和结构的方法。 由于信号转导过程对于细胞内和细胞间的通信是普遍的和基本的，因此更好地理解糖皮质激素受体信号传导途径以及多个信号输入可能会聚在单个因子上的机制对于分析许多生物信息的交易通常是重要的。 ***