Molecular Quantitative Genetics of Inbreeding Depression and Hybrid Breakdown in Arabidopsis

拟南芥近交衰退和杂种崩溃的分子定量遗传学

• 批准号: 9307747
• 负责人: Thomas Mitchell-Olds
• 金额: $ 26.5万
• 依托单位: University of Montana
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9307747&HistoricalAwards=false
• 关键词: Molecular; Quantitative; Genetics; Inbreeding; Depression

9307747 Mitchell Olds Molecular Biological approaches to quantitative genetics can be used to study in breeding depression and hybrid breakdown. The genetic basis of inbreeding dpression is an unanswered question with implications for many problems in agriculture and genetics. For example, hybrid vigor (avoidance of inbreeding depression) is responsible for a large portion of the increases in crop yield obtained by plant breeders. Crosses between distantly related populations may produce offspring with reduces fitness (hybrid breakdown). Phenotypic plasticity and genotype environment interaction may also be important in agricultural and wild species. Despite many years of inquiry, the genetic basis of these phenomena remains unclear. %%% Using recently developed techniquesin molecular biology it is now feasible to elucidate the genetic basis of ombreeding depression and outbreeding depression. This technology will be used to ask 1) What causes hybrid vigor? 2) Does genotype environment interaction contribute to hybrid vigor? 3) How do changes in gene expression cause genotype environment interaction? 4) What causes hybrid breakdown? This research will have important implications for understanding the genetics of agricultural and natural populations.

9307747名米切尔老人数量遗传学的分子生物学方法可以用来研究繁殖、抑郁和杂交崩溃。近亲繁殖衰退的遗传基础是一个尚未解答的问题，涉及到农业和遗传学中的许多问题。例如，杂交活力(避免近亲繁殖衰退)是植物育种者获得的作物产量增加的很大一部分原因。远亲群体之间的杂交可能产生适合度降低的后代(杂交失败)。表型可塑性和基因环境互作在农业和野生物种中也可能是重要的。尽管进行了多年的调查，但这些现象的遗传基础仍然不清楚。%利用最近发展起来的分子生物学技术，现在阐明异交抑制和异交抑制的遗传基础是可行的。这项技术将被用来问：1)是什么导致了杂交优势？2)基因环境互作对杂交优势有贡献吗？3)基因表达的变化是如何导致基因环境互作的？4)是什么导致了杂交失败？这项研究将对理解农业和自然种群的遗传学具有重要意义。