Organoiron Complexes in Organic Synthesis

9308105皮尔逊这项研究的重点是开发使用各种有机铁络合物形成碳-碳键的新方法。将研究有机铁化学的四个具体方面。第一方面研究了从二烯基络合物生成自由基的新方案，以及它们与侧链烯基的分子内偶联形成碳环环系统。这代表了有机金属自由基在合成有用的过程中的第一次应用。第二方面研究了铁促进的二炔和烯炔的碳化环化反应的扩展和应用，以形成环戊二烯铁络合物和环戊烯酮。第三个领域探索了环己二烯基阳离子的分子内碳亲核加成反应，为构建密集官能化分子提供了重要的新方法。最后一个方面是利用有机铁部分在八元环的多官能化过程中控制立体化学的能力，这在传统上是很难处理的；有机金属化学的使用为构象和立体化学控制问题提供了解决方案。有了这个奖项，合成有机计划将支持凯斯西储大学化学系的Anthony J.Pearson博士的研究。皮尔逊教授将专注于合成方法学领域的工作，开发使用各种有机铁络合物形成碳-碳键的新方法。***

9308105 Pearson The focus of this research is the development of new methods for carbon-carbon bond formation using a variety of organoiron complexes. There are four specific aspects of organoiron chemistry that will be studied. The first aspect investigates new protocols for the generation of free radicals from dienyliron complexes and their intramolecular coupling with pendant olefinic groups to form carbocyclic ring systems. This represents the first application of organometallic free radicals in synthetically useful processes. The second aspect studies extensions and applications of iron-promoted carbonylative annulation of diynes and enynes for formation of cyclopentadienoneiron complexes and cyclopentenones. The third area explores intramolecular carbon nucleophile additions to cyclohexadienyliron cations to provide important new methods for the construction of densely functionalized molecules. The final aspect exploits the ability of an organoiron moiety to control stereochemistry during multiple functionalization of eight-membered rings, which are traditionally difficult to handle; the use of organometallic chemistry provides solutions to problems of conformational and stereochemical control. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Anthony J. Pearson of the Department of Chemistry at Case Western Reserve University. Professor Pearson will focus his work in the area of synthetic methodology developing new methods for carbon-carbon bond formation using a variety of organoiron complexes. ***