Research Initiation Award: Block Copolymer Adsorption to Self-Assembled Lipid Monolayers

研究启动奖：嵌段共聚物对自组装脂质单层的吸附

• 批准号: 9308569
• 负责人: Robert Tilton
• 金额: $ 10万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1996-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9308569&HistoricalAwards=false
• 关键词: Research; Initiation; Award; Block; Copolymer

CTS-9308569 Carnegie Mellon University Robert D. Tilton ABSTRACT The objective of this research is to determine the mechanism of adsorption of block copolymers to the surface of self-assembled lipids at the vapor-water interface. Scanning angle reflectometry will be used to measure time-resolved layer thicknesses and refractive indexes as the block copolymers adsorb. Additional experiments in a Langmuir trough focus on determining the effect of the copolymer on -A isotherms. Kinetic and equilibrium results from these and other measurements will be used to help understand the interaction between the block copolymer molecules and the lipid aggregate. The presence of block copolymer amphiphiles can improve many existing and emerging technologies which support a variety of consumer products. They help to inhibit lysis of red blood cells, to reduce rupture of eucaryotic cells in cultures, and to stabilize emulsions.

摘要本研究的目的是确定嵌段共聚物在汽-水界面处自组装脂类表面的吸附机理。扫描角反射法将用于测量嵌段共聚物吸附时的时间分辨层厚度和折射率。在Langmuir槽中进行的其他实验着重于确定共聚物对-A等温线的影响。这些和其他测量的动力学和平衡结果将用于帮助理解嵌段共聚物分子和脂质聚集体之间的相互作用。嵌段共聚物两亲体的存在可以改善许多现有的和新兴的技术，支持各种消费产品。它们有助于抑制红细胞的裂解，减少培养中真核细胞的破裂，并稳定乳剂。