Molecular Design and Chemo-enzymatic Synthesis

分子设计和化学酶合成

• 批准号: 9310081
• 负责人: Chi-Huey Wong
• 金额: $ 44.26万
• 依托单位: The Scripps Research Institute
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9310081&HistoricalAwards=false
• 关键词: Molecular; Design; Chemo; enzymatic; Synthesis

The focus of this research is twofold. The first goal is the development of better enzymes for the synthesis of peptides and their isosteric and glycosylated derivatives and for the oxidation and halohydration of olefins. The second goal is the development of chemical/enzymatic strategies for the synthesis and use of sugar nucleotide and oligosaccharide mimetics. The project will advance our understanding of biomolecular recognition and catalysis and provide new methodologies and strategies for asymmetric synthesis that complement abiological approaches. %%% With this Accomplishment Based Award, the Synthetic Organic Program is supporting the research of Dr. Chi-Huey Wong of the Department of Chemistry at Scripps Clinic and Research Foundation. Professor Wong will focus his work on the development of novel enzymatic catalysts for use in the key-step synthesis of designed molecules with biological significance.

这项研究的重点是双重的。第一个目标是 开发用于合成肽的更好的酶， 它们的电子等排和糖基化衍生物， 烯烃的氧化和卤化水合。 第二个目标是 开发用于合成的化学/酶促策略 以及糖核苷酸和寡糖模拟物的用途。 的 该项目将促进我们对生物分子 识别和催化，并提供新的方法， 不对称合成的策略， 接近。 %%% 有了这个基于成就的奖项，合成有机 该计划正在支持黄志辉博士的研究， 斯克里普斯诊所和研究所化学系 基金会 黄教授的研究将集中于 开发新的酶催化剂用于 关键步骤合成设计的分子与生物 意义