Photochemical Alternatives for Pollution Prevention

9310097 Kraus本研究的重点是使用光化学方法替代刘易斯酸催化的Friedel-Crafts方法，该方法用于生产化合物，如地西泮、佐美酸、醋丁洛尔、布洛芬和多塞平。第二个项目涉及开发聚合物支持的试剂，以取代铬酸将醇氧化为酮。 有了这个环境友好的化学合成和加工奖，合成有机计划是支持乔治的研究。爱荷华州州立大学化学系的克劳斯说。 Kraus博士将把工作重点放在商业规模反应的光化学替代品上，现在需要氯化铝或铬酸作为关键试剂。 这种方法将消除大量有毒副产品的生产。 ***

9310097 Kraus The focus of this research is the use of a photochemical alternative to the Lewis acid catalyzed Friedel-Crafts processes used in the production of compounds such as diazepam, zomepirac, acebutolol, ibuprofen and doxepin. A second project involves the development of polymer-supported reagents to supplant chromic acid for the oxidation of alcohols to ketones. %%% With this Environmentally Benign Chemical Synthesis and Processing award, the Synthetic Organic Program is supporting the research of Dr. George A. Kraus of the Department of Chemistry at Iowa State University. Dr. Kraus will focus his work on a photochemical alternatives to commercial scale reactions now requiring aluminum chloride or chromic acid as key reagents. The approach would eliminate the production of vast quantities of toxic by-products. ***