Photochemical Alternatives for Pollution Prevention

预防污染的光化学替代品

• 批准号: 9310097
• 负责人: George Kraus
• 金额: $ 24.9万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9310097&HistoricalAwards=false
• 关键词: Photochemical; Alternatives; Pollution; Prevention

9310097 Kraus The focus of this research is the use of a photochemical alternative to the Lewis acid catalyzed Friedel-Crafts processes used in the production of compounds such as diazepam, zomepirac, acebutolol, ibuprofen and doxepin. A second project involves the development of polymer-supported reagents to supplant chromic acid for the oxidation of alcohols to ketones. %%% With this Environmentally Benign Chemical Synthesis and Processing award, the Synthetic Organic Program is supporting the research of Dr. George A. Kraus of the Department of Chemistry at Iowa State University. Dr. Kraus will focus his work on a photochemical alternatives to commercial scale reactions now requiring aluminum chloride or chromic acid as key reagents. The approach would eliminate the production of vast quantities of toxic by-products. ***

本研究的重点是利用光化学方法替代Lewis酸催化的Friedel-Crafts工艺，该工艺用于生产地西泮、zomepirac、acetbutolol、ibuprofen和doxpin等化合物。第二个项目涉及开发聚合物支撑试剂，以取代铬酸，使醇氧化为酮。有了这个环境友好的化学合成和加工奖，合成有机项目正在支持爱荷华州立大学化学系的乔治·a·克劳斯博士的研究。克劳斯博士将把他的工作重点放在光化学替代品上，以取代目前需要氯化铝或铬酸作为关键试剂的商业规模反应。这种方法将消除大量有毒副产品的产生。＊＊＊