Chimeric molecules for precision protein modification

用于精确蛋白质修饰的嵌合分子

• 批准号: DE230101236
• 负责人: Dr Xuyu Liu
• 金额: $ 31.3万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101236
• 关键词: Chimeric; molecules; precision; protein; modification

This project aims to address fundamental questions on how natural modifications of proteins cause functional changes inside cells. The project expects to generate new knowledge in the areas of organic chemistry and chemical biology through the development of a synthetic platform for the discovery of a novel class of chimeric molecules that can trigger precise modifications of proteins. Expected outcomes include a detailed understanding of how specific modifications modulate protein and cellular function. Significant benefits of this interdisciplinary project include access to a new class of molecules for basic research that may also find use for cell engineering applications within the growing biotechnology sector in Australia.

该项目旨在解决蛋白质的自然修饰如何引起细胞内功能变化的基本问题。该项目预计将通过开发一个合成平台来发现一类新型嵌合分子，从而在有机化学和化学生物学领域产生新的知识，这些嵌合分子可以引发蛋白质的精确修饰。预期成果包括详细了解特定修饰如何调节蛋白质和细胞功能。这一跨学科项目的重大好处包括获得一类新的分子用于基础研究，也可能在澳大利亚不断增长的生物技术领域中用于细胞工程应用。