Angiotensin II-Induced Water Absorption Behavior

血管紧张素 II 诱导的吸水行为

• 批准号: 9310352
• 负责人: Catherine Propper
• 金额: $ 18万
• 依托单位: Northern Arizona University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9310352&HistoricalAwards=false
• 关键词: Angiotensin; II; Induced; Water; Absorption

9310352 Propper Angiotensin II is a peptide antidiuretic hormone involved in maintaining water balance by acting both on peripheral targets to enhance water uptake across tissues and on the central nervous system to induce drinking behavior. Since water is essential for survival, understanding how this hormone enhances water-absorption is of utmost importance. The mechanism, however, by which angiotensin II acts in the brain is not well understood. While most vertebrates have a regular and predictable water supply, desert animals live in harsh conditions in which survival is dependent upon the ability to find, obtain and conserve water. These species have evolved mechanisms of water retention which allows them to survive under these uncharitable conditions. Dr. Propper has selected two species that differ in genetic background but live within the same austere environment. She will employ a combination of behavioral, neuroanatomical and endocrine techniques to determine the underlying mechanisms of Angiotensin 11 action. Dr. Propper will determine whether centrally administering this peptide induces water absorption behavior, and whether the behavior is blocked by antagonists to the receptor. Moreover, Dr. Propper will localize and characterize these angiotensin II receptors in the brain. Finally, she will determine the effects that dehydration has on central and peripheral receptor concentrations and correlate these changes with behavior in the natural environment. The results from this integrative work will provide new insights into the neural mechanisms underlying angiotensin action. Furthermore, since Dr. Propper is comparing species that differ in their genetic background, she will discover whether similar neuroendocrine mechanisms are employed to manage water balance in vertebrates in general. These findings may lead to a better understanding of how the neuroendocrine basis of adaptive behavior has evolved. ***

9310352 Propper Angiotensin II 是一种肽类抗利尿激素，通过作用于外周目标以增强跨组织的水吸收和作用于中枢神经系统以诱导饮水行为，从而维持水平衡。 由于水对于生存至关重要，因此了解这种激素如何增强吸水性至关重要。 然而，血管紧张素 II 在大脑中发挥作用的机制尚不清楚。 虽然大多数脊椎动物都有规律且可预测的水供应，但沙漠动物却生活在恶劣的条件下，其生存依赖于寻找、获取和保存水的能力。 这些物种进化出了保水机制，使它们能够在这些恶劣的条件下生存。 普罗珀博士选择了两个遗传背景不同但生活在相同严峻环境中的物种。 她将结合行为、神经解剖学和内分泌技术来确定血管紧张素 11 作用的潜在机制。 Propper 博士将确定集中施用这种肽是否会诱导吸水行为，以及该行为是否会被受体拮抗剂阻断。 此外，Propper 博士还将对大脑中的这些血管紧张素 II 受体进行定位和表征。 最后，她将确定脱水对中枢和外周受体浓度的影响，并将这些变化与自然环境中的行为联系起来。 这项综合工作的结果将为血管紧张素作用的神经机制提供新的见解。 此外，由于普罗珀博士正在比较遗传背景不同的物种，她将发现脊椎动物是否普遍采用类似的神经内分泌机制来管理水平衡。 这些发现可能有助于更好地理解适应性行为的神经内分泌基础是如何进化的。 ***