Steroidogenic Factor 1 and Neuroendocrine Control of Seasonal Reproduction

类固醇生成因子 1 和季节性繁殖的神经内分泌控制

• 批准号: 9874481
• 负责人: Catherine Propper
• 金额: $ 5万
• 依托单位: Northern Arizona University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9874481&HistoricalAwards=false
• 关键词: Steroidogenic; Factor; Neuroendocrine; Control; Seasonal

Seasonal reproduction in vertebrates is often characterized by specific increases in gonadal activity that is regulated by changes in steroid hormone production. These changes are often under control of the environment. However, the exact molecular mechanism that initiates the cascade of hormonal events set off by the changing environment is unknown. Steroidogenic Factor 1 (SF-1) is a protein that plays a vital role in inducing reproductively in appropriate hormone and receptor synthesis in several tissues. Dr. Propper and her associates propose that SF-1 may play a fundamental role in mediating environmentally regulated seasonal reproduction. In order to begin studies on the role of SF-1 in seasonal reproduction, she proposes to determine the amino acid sequence of SF-1 in an amphibian whose pattern of seasonal reproduction has been well-defined (American bullfrog, Rana catesbeiana). She will also determine the tissue and cell distribution of SF-1 in this species.

脊椎动物的季节性繁殖通常以性腺活动的特定增加为特征，性腺活动由类固醇激素产生的变化来调节。 这些变化往往受环境的控制。 然而，引发由环境变化引起的激素事件级联的确切分子机制尚不清楚。 类固醇生成因子1（SF-1）是一种蛋白质，在诱导生殖的适当激素和受体的合成在几个组织中起着至关重要的作用。 Propper博士和她的同事提出，SF-1可能在调节环境调节的季节性生殖中发挥重要作用。 为了开始研究SF-1在季节性繁殖中的作用，她建议确定季节性繁殖模式已经明确的两栖动物（美国牛蛙）中SF-1的氨基酸序列。 她还将确定SF-1在该物种中的组织和细胞分布。