Development of the Visual Projection in the Embryo

小行星9311198 该项目将研究大脑发育过程中某些特定分子的生物学意义。 该项目将测试神经细胞过程或生长锥的生长尖端使用细胞外基质分子和特定细胞粘附分子的受体通过大脑导航到适当的目标的假设。 这些分子的作用将使用功能阻断剂在发展中的视觉系统的特点。 此外，生物化学，免疫学和分子技术的组合将用于检查这些分子在发育过程中的空间和时间分布。 这些研究的结果将提供重要的新信息的细胞和分子基础上的生长锥的指导和途径的选择。 长期目标是更好地了解在发育过程中调节特定神经连接形成的细胞和分子机制。 *** 小行星9311198 本项目将研究某些特定分子在发展过程中的生物学意义。 | ~ W | ~ ! !. !. F ~ ~ ( Times New Roman 符号Arial " H ? ? 萨卡 William普罗克特，IBN William普罗克特，IBN

9311198 Sakaguchi This project will investigate the biological significance of certain specific molecules during the development of the brain . This project will test the hypothesis that the growing tips of nerve cell processes, or growth cones, use receptors for extracellular matrix molecules and specific cell adhesion molecules to navigate through the brain to their appropriate targets. The role of these molecules will be characterized using function-blocking reagents in the developing visual system. In addition, a combination of biochemical , immunological and molecular techniques will be used to examine the spatial and temporal distribution of these molecules during development. The results of these studies will provide important new information on the cellular and molecular basis of growth cone guidance and pathway selection. The longer term goal is to better understand the cellular and molecular mechanisms that regulate the formation of specific nerve connections during development. *** 9311198 Sakaguchi This project will investigate the biological significance of certain specific molecules during the develop | ~ w | ~ ! !. !. F ~ ~ ( Times New Roman Symbol & Arial " h ? ? saka William Proctor, IBN William Proctor, IBN