CCK Receptors: Brain and Behavior

CCK 受体：大脑和行为

• 批准号: 9311054
• 负责人: Donald Sakaguchi
• 金额: $ 19.9万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 2000-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9311054&HistoricalAwards=false
• 关键词: CCK; Receptors; Brain; Behavior

9311054 Jacobson Cholecystokinin (CCK) is one of the most abundant peptides found in the mammalian central nervous system. It appears to modulate many centrally controlled functions, including respiration, thermoregulation, reproduction, nociception, anxiety, and memory. By far the best-known role of CCK, however, is its action as a feeding satiety factor. Recently, Dr. Jacobson found CCK receptor binding in the facial motor nucleus, a substrate that mediates facial movement or expression, including nursing. Therefore, Dr. Jacobson speculates that CCK may also have a central effect on motor systems involved in the control of feeding-related behaviors. Utilizing the methods of immunohistochemistry and receptor autoradiography, she will determine if the cholecystokininergic system is playing a role in nursing behavior. Dr. Jacobson will compare the distribution of CCK receptors in neurons located within the Vllm nucleus which innervates facial muscles in neonates of different species. She will then use a metabolic marker to determine how manipulations in feeding, and the exogenous administration of CCK or its antagonists, affect the activity of neurons in developing motor systems. The results from these studies will further our knowledge on the central mediation of feeding behavior, and the role of cholecystokininergic system in this process. Understanding this fundamental mechanism could in turn have beneficial effects on management of obesity and eating disorders. ***

小行星9311054 胆囊收缩素（CCK）是哺乳动物中枢神经系统中含量最丰富的多肽之一。 它似乎调节许多中枢控制的功能，包括呼吸、体温调节、生殖、伤害感受、焦虑和记忆。 然而，到目前为止，CCK最著名的作用是其作为进食饱腹感因子的作用。 最近，雅各布森博士发现CCK受体结合在面部运动核中，这是一种介导面部运动或表达的底物，包括护理。 因此，Jacobson博士推测，CCK也可能对参与控制喂食相关行为的运动系统产生重要影响。 利用免疫组织化学和受体放射自显影的方法，她将确定胆囊收缩素能系统是否在护理行为中发挥作用。 Jacobson博士将比较CCK受体在位于Vllm核内的神经元中的分布，Vllm核支配不同物种的新生儿的面部肌肉。 然后，她将使用代谢标记物来确定喂养中的操作以及CCK或其拮抗剂的外源性给药如何影响发育中运动系统的神经元活性。 这些研究结果将有助于我们进一步了解摄食行为的中枢调节机制，以及胆囊收缩素能系统在这一过程中的作用。 了解这一基本机制反过来可能对肥胖和饮食失调的管理产生有益的影响。 ***