Modulating protein phase behavior: cell functions vs material development

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It has been recognized recently that cellular proteins can undergo liquid-liquid phase separation, however, a further liquid-to-solid transition can lead to aberrant biological processes. This project aims to investigate and control this behaviour to gain insights into cell dysfunction and new routes for biomaterials development. An integrated approach combining microfluidic platforms, optical techniques, and vibrational spectroscopy will be exploited. Expected outcomes of this project include the mechanistic understanding of protein phase behaviour and protein-based biomaterial engineering. This should provide significant benefits in the prevention of aberrant protein aggregation and the generation of materials as plastic substitutes.