Synthesis, Reactivity and Catalysis of Novel Metallacarboranes

这个无机、生物无机和有机金属项目的奖项为加州大学洛杉矶分校化学系的M. Frederick Hawthorne博士对碳硼烷和金属碳硼烷的研究提供了持续的支持。不同的结构原子排列，如“碳环”和“碳元”将连接成大型的“超分子”结构。通过控制这些簇的大小和形状，可以构造出许多不同大小、形状和电子性质的笼，这些笼可以用来捕获小离子和分子。一些最具挑战性的目标分子将具有适当大小的“孔”，以容纳三个过渡金属离子。此外，还研究了镧系金属碳硼烷的反应性和酸性。为了获得选择性阴离子载体，将研究亲电性碳汞基载体在各种新化合物中的结合能力。将制备具有特定手性和结合力的超分子结构。含有硼、碳和金属原子的大的、有规则几何形状的新分子将被合成。这种结构足够大，可以“俘获”其他原子或小分子。由于这些结构对带负电荷的离子具有吸引力，并且由于陷阱的大小、形状和强度是可以控制的，因此它们作为“离子通道”具有很大的潜力，可以在生命系统中运输离子。它们也可以作为有效的分析探针或酸催化剂。本基础研究涉及分子识别、均相催化、化学传感器制造和生物分子修饰。​## !​!!f# # (Times New Roman Symbol & Arial " h 1 = Margaret A. Cavanaugh

This award in the Inorganic, Bioinorganic, and Organometallic Program provides continued support for research on carboranes and metallocarboranes by Dr. M. Frederick Hawthorne of the Chemistry Department, University of California at Los Angeles. Diverse structural atomic arrangements such as "carboracycles" and "carborods" will be linked into large "supramolecular" structures. By controlling the size and shape of these clusters, cages of many different sizes, shapes, and electronic properties which can be used for capturing small ions and molecules will be constructed. Some of the most challenging target molecules will have "holes" of the appropriate size to contain three transition metal ions. In addition, the reactivity and acidity of carboranes of lanthanide metals will be investigated. The binding capabilities of electrophilic mercuracarborand hosts will be studied in a variety of new compounds in order to obtain selective anion carriers. Supramolecular structures with specific chirality and binding power will be prepared. Large new molecules of regular geometry which contain boron, carbon, and metal atoms will be synthesized. The structures are sufficiently large that they can "capture" other atoms or small molecules. Because these structures are attractive to negatively charged ions and because the size, shape, and strength of the traps can be controlled, they have great potential as "ion channels" which can transport ions in living systems. They also could be effective as analytical probes or as acid catalysts. This basic reseach is relevant to molecular recognition, homogeneous catalysis, chemic al sensor fabrication and biomolecule modification. # # ! ! ! F # # ( Times New Roman Symbol & Arial " h 1 = Margaret A. Cavanaugh Margaret A. Cavanaugh