Synthesis, Reactivity and Catalysis of Novel Metallacarboranes

该奖项在无机，生物无机和有机物计划提供了持续的支持碳硼烷和碳硼烷的研究由博士M。洛杉矶加州大学化学系的弗雷德里克霍桑说。 不同的结构原子排列，如“碳杂环”和“碳环”将被连接成大的“超分子”结构。 通过控制这些团簇的大小和形状，将构建许多不同大小、形状和电子性质的笼，这些笼可用于捕获小离子和分子。 一些最具挑战性的目标分子将具有适当大小的“孔”，以包含三个过渡金属离子。 此外，镧系金属碳硼烷的反应性和酸性也将被研究。 将在各种新化合物中研究亲电汞碳硼主体的结合能力，以获得选择性阴离子载体。 将制备具有特定手性和结合力的超分子结构。 将合成含有硼、碳和金属原子的规则几何形状的新大分子。 这些结构足够大，可以“捕获”其他原子或小分子。 由于这些结构对带负电荷的离子具有吸引力，并且由于陷阱的大小，形状和强度可以控制，因此它们具有作为“离子通道”的巨大潜力，可以在生命系统中运输离子。 它们也可以有效地作为分析探针或酸催化剂。 这一基础研究与分子识别、均相催化、化学传感器的制备和生物分子的修饰有关。 # # ! ! ! F # # ( Times New Roman 符号Arial " H 1 = Margaret A.玛格丽特·A·卡瓦诺Cavanaugh

This award in the Inorganic, Bioinorganic, and Organometallic Program provides continued support for research on carboranes and metallocarboranes by Dr. M. Frederick Hawthorne of the Chemistry Department, University of California at Los Angeles. Diverse structural atomic arrangements such as "carboracycles" and "carborods" will be linked into large "supramolecular" structures. By controlling the size and shape of these clusters, cages of many different sizes, shapes, and electronic properties which can be used for capturing small ions and molecules will be constructed. Some of the most challenging target molecules will have "holes" of the appropriate size to contain three transition metal ions. In addition, the reactivity and acidity of carboranes of lanthanide metals will be investigated. The binding capabilities of electrophilic mercuracarborand hosts will be studied in a variety of new compounds in order to obtain selective anion carriers. Supramolecular structures with specific chirality and binding power will be prepared. Large new molecules of regular geometry which contain boron, carbon, and metal atoms will be synthesized. The structures are sufficiently large that they can "capture" other atoms or small molecules. Because these structures are attractive to negatively charged ions and because the size, shape, and strength of the traps can be controlled, they have great potential as "ion channels" which can transport ions in living systems. They also could be effective as analytical probes or as acid catalysts. This basic reseach is relevant to molecular recognition, homogeneous catalysis, chemic al sensor fabrication and biomolecule modification. # # ! ! ! F # # ( Times New Roman Symbol & Arial " h 1 = Margaret A. Cavanaugh Margaret A. Cavanaugh