Synthesis, Reactivity and Catalysis of Novel Metallacarboranes

这个无机、生物无机和有机金属化学项目的奖项支持加州大学洛杉矶分校弗雷德里克·霍桑博士实验室的研究。这项研究涉及到基于二十面体碳硼烷的大分子组装体的发展。利用亲核取代、二核苷制备或亲电卤化，邻位、间位和对二十面体碳硼烷将被疏水或亲水基团功能化。线性组合物，碳硼化合物，可以单独使用对碳硼烷或与线性双官能团结合来合成。研究了碳原子的离子缔合和热致液晶特性。环组合物，碳环和汞环化合物，将由邻碳硼烷或间碳硼烷和双官能团间隔基合成。研究了碳环和碳碳化合物的主客体相互作用、亲电催化活性和溶变液晶特性。其他的研究课题包括十烷基甲基对碳硼烷的功能化和双碳内酯反应性的研究。对分子自组装的探索将导致独特分子结构的发展，并促进我们对结构和功能相互关系的理解。这项研究可能会导致分子识别分析探针和新的催化剂的发展。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry Program supports research in the laboratories of Dr. M. Frederick Hawthorne at the University of California, Los Angeles. The research to be performed involves the development of macromolecular assemblies based upon icosahedral carboranes. Utilizing nucleophilic substitution, dicarbollide preparation, or electrophilic halogenation, ortho-, meta-, and para-icosahedral carboranes will be functionalized with hydrophobic or hydrophilic moieties. Linear assemblies, carborods, will be synthesized using para-carboranes alone or in combination with linear-bifunctional linking groups. The ionic association and thermotropic liquid-crystal characteristics of carborods will be examined. Cyclic assemblies, carboracycles and mercuracarborands, will be synthesized using ortho- or meta- carboranes and bifunctional-spacer groups. The host-guest interactions, electrophilic catalytic activity, and lyotropic liquid-crystal characteristics of carboracycles and mercuracarborands will be investigated. Additional research topics include the functionalization of decakismethyl para-carborane and investigation of dicarbollide reactivity. Exploration of molecular self-assembly will lead to the development of unique molecular architectures and advance our understanding of the interrelationship of structure and function. This research may lead to the development of analytical probes for molecular recognition and new catalysts.