Synthesis, Reactivity and Catalysis of Novel Metallacarboranes

该奖项在无机，生物无机和有机化学 该计划支持M博士实验室的研究。弗雷德里克 霍桑在洛杉矶的加州大学。了研究 涉及开发大分子组装体， 二十面体碳硼烷。利用亲核取代， 二碳环内酯制备，或亲电卤化，邻位，Meta位， 和对位二十面体碳硼烷将被疏水官能化， 或亲水部分。线性组件，碳纤维，将是 单独使用对位碳硼烷或与 线性双官能连接基团。离子缔合， 碳纤维的热致液晶特性将是 考察循环组件，碳环化合物和汞碳硼化合物， 使用邻位或Meta位碳硼烷和双官能间隔基合成 组 主客体相互作用，亲电催化活性， 和碳硼烷的溶致液晶特性， 将对汞碳化合物进行调查。其他研究课题 包括十烷基甲基对碳硼烷的官能化， 研究二卡波内酯反应性。 对分子自组装的探索将导致 独特的分子结构，并推进我们对 结构与功能的相互关系。这项研究可能会导致 用于分子识别的分析探针的开发和新的 催化剂的

This award in the Inorganic, Bioinorganic and Organometallic Chemistry Program supports research in the laboratories of Dr. M. Frederick Hawthorne at the University of California, Los Angeles. The research to be performed involves the development of macromolecular assemblies based upon icosahedral carboranes. Utilizing nucleophilic substitution, dicarbollide preparation, or electrophilic halogenation, ortho-, meta-, and para-icosahedral carboranes will be functionalized with hydrophobic or hydrophilic moieties. Linear assemblies, carborods, will be synthesized using para-carboranes alone or in combination with linear-bifunctional linking groups. The ionic association and thermotropic liquid-crystal characteristics of carborods will be examined. Cyclic assemblies, carboracycles and mercuracarborands, will be synthesized using ortho- or meta- carboranes and bifunctional-spacer groups. The host-guest interactions, electrophilic catalytic activity, and lyotropic liquid-crystal characteristics of carboracycles and mercuracarborands will be investigated. Additional research topics include the functionalization of decakismethyl para-carborane and investigation of dicarbollide reactivity. Exploration of molecular self-assembly will lead to the development of unique molecular architectures and advance our understanding of the interrelationship of structure and function. This research may lead to the development of analytical probes for molecular recognition and new catalysts.