Role of Serotonin in Feeding Arousal in a Mollusc

小行星9319927 动物和人类的行为唤醒发生在几个独立行为发生变化时，以便整体行为输出更加集中或有效。 行为唤醒是一个重要的问题，但在细胞水平上还没有得到很好的理解。在海洋软体动物Clione当猎物是附近，喂养唤醒反应发生，其中有一个降低的阈值开始喂养行为，增加游泳速度更有效的猎物捕获，增加心率和抑制的撤回反应。 这项工作将研究神经系统中引起这种行为状态变化的细胞机制，并研究大脑化学物质5-羟色胺在这种行为中的作用。 克隆是一种很好的研究行为唤醒的动物，因为构成组成行为（进食、游泳和退缩）的神经回路已经被PI和其他人研究出来，个体神经细胞的水平也已经被PI和其他人研究出来。PI还表明，向动物注射5-羟色胺会导致进食唤醒行为，并且Clione神经系统中的细胞含有5-羟色胺。***

9319927 Satterlie Behavioral arousal in animals and humans occurs when there is a change in several independent behaviors so that the overall behavioral output is more focussed or efficient. Behavioral arousal is an important issue that is not well-understood at the cellular level. In the marine mollusc Clione when prey is nearby, a feeding arousal response occurs in which there is a decreased threshold for starting the feeding behavior, an increase in swimming speed for more efficient prey capture, an increase in heart rate and an inhibition of the withdrawal response. This work will investigate the cellular mechanisms in the nervous system that give rise to this change in behavioral state and examine the role of the brain chemical serotonin in this behavior. Clione is an excellent animal in which to study behavioral arousal because the neural circuits that underlie the component behaviors (feeding, swimming, and withdrawal) have already been worked out and the level of individual nerve cells by the PI and others. The PI has also shown that injection of serotonin into the animal results in feeding arousal behavior and that there are cells in the Clione nervous system that contain serotonin. ***