Role of Serotonin in Feeding Arousal in a Mollusc

9319927 Satterlie在动物和人类中，当几个独立的行为发生变化，从而使整体行为输出更集中或更有效时，就会发生行为唤醒。行为唤醒是一个重要的问题，但在细胞水平上还没有得到很好的理解。在海洋软体动物克隆体中，当猎物在附近时，会产生一种摄食唤醒反应，即开始摄食行为的阈值降低，游动速度加快以更有效地捕获猎物，心率增加，戒断反应受到抑制。这项工作将研究神经系统中引起这种行为状态变化的细胞机制，并研究大脑化学物质血清素在这种行为中的作用。克隆龙是研究行为唤醒的优秀动物，因为构成其组成行为（进食、游泳和退缩）的神经回路已经被PI和其他人研究出来了，而且单个神经细胞的水平也已经被研究出来了。PI还表明，在动物体内注射血清素会导致喂养行为的唤醒，并且克隆动物的神经系统中有细胞含有血清素。＊＊＊

9319927 Satterlie Behavioral arousal in animals and humans occurs when there is a change in several independent behaviors so that the overall behavioral output is more focussed or efficient. Behavioral arousal is an important issue that is not well-understood at the cellular level. In the marine mollusc Clione when prey is nearby, a feeding arousal response occurs in which there is a decreased threshold for starting the feeding behavior, an increase in swimming speed for more efficient prey capture, an increase in heart rate and an inhibition of the withdrawal response. This work will investigate the cellular mechanisms in the nervous system that give rise to this change in behavioral state and examine the role of the brain chemical serotonin in this behavior. Clione is an excellent animal in which to study behavioral arousal because the neural circuits that underlie the component behaviors (feeding, swimming, and withdrawal) have already been worked out and the level of individual nerve cells by the PI and others. The PI has also shown that injection of serotonin into the animal results in feeding arousal behavior and that there are cells in the Clione nervous system that contain serotonin. ***