Neurotransmitter Specification and Regulation

神经递质规格和调节

• 批准号: 9320262
• 负责人: Christine Li
• 金额: $ 30.94万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1998-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9320262&HistoricalAwards=false
• 关键词: Neurotransmitter; Specification; Regulation

9310162 Li Neurotransmitters are the molecular compounds that are used for communication signals between nerve cells, or neurons, in the brain. Development of the proper neurotransmitters is critical to the normal development of the nervous system in any animal, to establish and regulate communication between the nerve cells. This project exploits the extremely simple nervous system of a tiny roundworm, known as C. elegans, which has the added advantage of allowing sophisticated genetic studies. A gene called flp-1 has been discovered to encode a group of compounds called FRMF amide- like peptides that are important neurotransmitters. This work will use molecular genetic techniques to examine the control of the transcription process underlying the expression of the peptides from the gene. The work will characterize the flp-1 gene, and identify the promoter elements and genes that interact with flp-1, important to the specification and regulation of neuropeptide expression. Molecular characterization of this genetic pathway may yield insights into the mechanisms of how neurons are developmentally programmed to express specific neurotransmitters, and results will have impact across many areas of neuroscience, genetics and developmental biology. ***

小行星9310162 神经递质是用于大脑中神经细胞或神经元之间通信信号的分子化合物。 适当的神经递质的发育对任何动物神经系统的正常发育至关重要，以建立和调节神经细胞之间的通信。 这个项目利用了一种叫做C. elegans，它有一个额外的优势，允许复杂的遗传研究。 一种名为flp-1的基因被发现编码一组名为FRMF酰胺样肽的化合物，这些化合物是重要的神经递质。 这项工作将使用分子遗传学技术来检查转录过程的控制，这些转录过程是从基因中表达肽的基础。 这项工作将描述flp-1基因的特征，并确定与flp-1相互作用的启动子元件和基因，这对神经肽表达的规范和调节很重要。 这种遗传途径的分子表征可能会深入了解神经元如何发育编程以表达特定神经递质的机制，结果将对神经科学，遗传学和发育生物学的许多领域产生影响。 ***