Identifying novel genes causing otosclerosis, the most common cause of progressive hearing loss in Caucasians worldwide, using Newfoundland's founder population.

利用纽芬兰的创始人人群识别导致耳硬化症的新基因，耳硬化症是全世界白种人进行性听力损失的最常见原因。

• 批准号: 207295
• 负责人: Young Terry-Lynn
• 金额: $ 18.25万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-03-01 至 2013-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=207295&lang=en
• 关键词: Family And Population Studies; Gene Mapping And Cloning; Gene-Gene Interactions; Genetics Of Deafness; Genotype-Phenotype Correlation; Isolated Population

Otosclerosis is a type of conductive hearing loss that affects adults in their 20s-30s and may progress to profound hearing loss. It is caused by abnormal overgrowth of the tiny bones in the middle ear, causing these normally mobile bones to "freeze". In

耳硬化是一种传导性听力损失，影响20 -30岁的成年人，并可能发展为深度听力损失。它是由中耳的小骨头异常过度生长引起的，导致这些正常活动的骨头“冻结”。在