NSF Young Investigator

NSF 青年研究员

• 批准号: 9358452
• 负责人: Wayne Curtis
• 金额: $ 32.25万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-10-15 至 1999-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9358452&HistoricalAwards=false
• 关键词: NSF; Young; Investigator

9358452 Curtis This award will focus on the scale-up of chemical production from plant tissue cultures. The potential of plant tissue cultures as sources of biologically active chemicals is exemplified by taxol, an anti-cancer drug recently approved by the FDA for treatment of ovarian cancer. Taxol is isolated from the bark of the Pacific yew tree. The yields from this tree are relatively low and several trees are required to treat a single patient. The tree is also slow growing, ie., it requires 100 years to mature, and has a very limited area of distribution. Plant cell cultures may provide an alternative for the production of taxol as well as other plant derived products, and thus provide a means of overcoming limitations in natural resources. ***

小行星9358452 该奖项将重点关注植物组织培养中化学品生产的规模扩大。 植物组织培养物作为生物活性化学物质来源的潜力以紫杉醇为例，紫杉醇是一种最近被FDA批准用于治疗卵巢癌的抗癌药物。 紫杉醇是从太平洋紫杉树的树皮中分离出来的。 这种树的产量相对较低，需要几棵树来治疗一个病人。 这棵树生长缓慢，它需要100年才能成熟，分布区域非常有限。 植物细胞培养可以为紫杉醇以及其他植物衍生产品的生产提供替代方案，从而提供克服自然资源限制的手段。 ***