Role of DCN1 in the regulation of the VHL tumour suppressor complex

DCN1在VHL肿瘤抑制复合物调节中的作用

• 批准号: 225374
• 负责人: Greer Samantha N
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-02-01 至 2012-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=225374&lang=en
• 关键词: Cancer Cell Lines; Cullin-2; E3 Ligase; Gel Electrophoresis; Hypoxia-Inducible Factor; Nedd8; Sccro; Squamous Cell Carcinoma; Von Hippel-Lindau Protein; Western Blotting

Hypoxia-inducible factor (HIF) is a transcription factor that promotes the intracellular production of specific proteins which allow the cell to adapt to low-oxygen environments, as in solid tumours. These proteins stimulate cellular responses, including

缺氧诱导因子(HIF)是一种转录因子，能促进细胞内特定蛋白质的产生，使细胞能够适应低氧环境，如实体肿瘤。这些蛋白质刺激细胞反应，包括