Middle T Antigen of Polyoma Virus-Mediated Activation of the Ras/Raf/MEK/ERK and Phosphoinositide 3-Kinase/Akt Signalling Pathways, and the Subsequent Effects on Gap Junctional Intercellular Communication

多瘤病毒中 T 抗原介导的 Ras/Raf/MEK/ERK 和磷酸肌醇 3-激酶/Akt 信号通路的激活以及对间隙连接细胞间通讯的后续影响

• 批准号: 200186
• 负责人: Greer Samantha N
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-02-01 至 2011-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=200186&lang=en
• 关键词: Cell Signalling; Cellular Transformation; Electroporation; Gap Junctions; Middle T; Mitogen Associated Protein Kinases; Oncogene; Phosphoinositide 3-Kinase; Polyoma Virus; Transfection

Cells that are in contact, as in tissues, may communicate via small transmembrane pores termed gap junctions. This intercellular communication is critical for regulation of normal cell processes such as growth, proliferation, and programmed self-destructi

接触的细胞，如在组织中，可能通过称为缝隙连接的跨膜小孔进行交流。这种细胞间通讯对于调节正常的细胞过程至关重要，如生长、增殖和程序性自毁