Impact of humoral immunity on nanoparticle–biological interactions

体液免疫对纳米颗粒生物相互作用的影响

• 批准号: DE230101542
• 负责人: Dr Yi Ju
• 金额: $ 31.72万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101542
• 关键词: Impact; humoral; immunity; nanoparticle; biological

This project aims to improve the biological applications of nanomaterials by understanding their fundamental interactions with proteins and cells in relevant biological environments. This will create new knowledge on how humoral (antibody-mediated) immunity affects nanomaterials using cutting-edge immunoassays, bio–nano characterisation techniques, and bioinformatics. Expected outcomes of the project include an understanding of how specific antibodies modulate the protein coatings on nanomaterials, which will shed light on how immune cells interact with nanomaterials. This will lead to design principles for nanomaterial properties to improve their effectiveness in delivering drugs and gene therapies.

该项目旨在通过了解纳米材料在相关生物环境中与蛋白质和细胞的基本相互作用来改善纳米材料的生物应用。这将创造关于体液（抗体介导的）免疫如何使用尖端免疫测定，生物纳米表征技术和生物信息学影响纳米材料的新知识。该项目的预期成果包括了解特定抗体如何调节纳米材料上的蛋白质涂层，这将揭示免疫细胞如何与纳米材料相互作用。这将导致纳米材料特性的设计原则，以提高其在提供药物和基因治疗方面的有效性。