Impact of Environmental Modifications on Pathogenesis and Immunity of Plasmodium falciparum and P. vivax Malaria
环境改造对恶性疟原虫和间日疟原虫疟疾发病机制和免疫的影响
基本信息
- 批准号:10382276
- 负责人:
- 金额:$ 40.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-04-15 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAfricaAfrica South of the SaharaAgricultureAnopheles GenusAntibodiesAntibody-mediated protectionAustraliaBehaviorBindingBiologicalBiological AssayBiomassBiostatistics CoreBlocking AntibodiesBloodClinical DataCollaborationsCommunity SurveysComplementCountryCulicidaeDataDemographyDetectionDevelopmentDiagnostic testsDiseaseEcosystemEnrollmentEnvironmentEnvironmental ImpactEpidemiologyErythrocytesEthiopiaEthiopianEthnic OriginExposure toGerm CellsGoalsHandHigh PrevalenceHumanHumoral ImmunitiesImmuneImmunityImmunoglobulin GImpairmentIn VitroIndividualInfectionInterventionIrrigationKenyaKnowledgeLogisticsMaintenanceMalariaMalaria preventionMediatingMembraneMembrane ProteinsMemory B-LymphocyteModificationMonitorMorbidity - disease rateOffice of Administrative ManagementParasitesPathogenesisPatternPeripheral Blood Mononuclear CellPersonsPhagocytosisPlasmaPlasmodium falciparumPlasmodium vivaxPopulationPopulation SurveillancePredictive ValuePredispositionPrevalenceProductivityProspective cohort studyProtein Binding DomainProteinsPublic HealthRecoveryResearchResearch Project GrantsResource-limited settingRoleSamplingScientistSerology testSiteSpecimenStandardizationSurfaceTimeVivax MalariaWateracquired immunityantibody testbaseblood groupdata exchangedata managementdiagnostic toolfeedingimprovedinsightlaboratory facilityland usemalaria infectionmalaria transmissionmalaria transmission-blocking vaccinenovelseroconversionsynergismtransmission processvector
项目摘要
PROJECT 3
PROJECT SUMMARY
Impact of Environmental Modifications on Pathogenesis and
Immunity of Plasmodium falciparum and P. vivax Malaria
Hydropower dam and irrigation initiatives to improve and sustain agricultural productivity are
underway in Ethiopia and Kenya. However, there is very limited knowledge of how these
water and land use modifications will affect diverse malaria ecosystems and impact ongoing
vector interventions that have decreased but not eliminated malaria transmission. Research
in this project will address topics pertinent to understanding how rapid changes in intensity
and geospatial features of Plasmodium falciparum vivax and P. vivax transmission resulting
from environmental modifications impact naturally acquired immunity (NAI) to malaria disease
pathogenesis and parasite transmission from humans to mosquitoes. From a translational
perspective, the goals are to 1) develop, evaluate and validate in vitro correlates of NAI
adaptable to standardized formats as population surveillance and diagnostic tools that could
be used to predict resurgences or reductions of malaria morbidity, and 2) advance
understanding of naturally acquired P. falciparum antibody-mediated transmission reducing
activity. From a basic perspective, our goals are to 1) define the mechanistic roles of
antibodies and complement in malaria immunity, and 2) fill in major gaps of knowledge
related to NAI to P. vivax pathogenesis in Africa. These goals will be achieved through a
collaboration involving field and laboratory facilities in two malaria endemic sites in western
Kenya and three malaria endemic sites in Ethiopia with malaria research teams in the U.S.
and Australia that have long standing working relationships with research scientists and
malaria public health experts in Ethiopia and Kenya. This is integrated with the Epidemiology
project, which will generate biological samples, clinical data, and antibody seroconversion
data, and the Transmission project, which will determine whether vector species composition,
biting behavior and spatial patterns of exposure to anopheline mosquitoes correlate with
changes in transmission reducing immunity. The Administrative and Data Management and
Biostatistics Cores will be critical to the logistics, management, and scientific value of this
project.
项目3
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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James Walter Kazura其他文献
James Walter Kazura的其他文献
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{{ truncateString('James Walter Kazura', 18)}}的其他基金
Impact of Environmental Modifications on Pathogenesis and Immunity of Plasmodium falciparum and P. vivax Malaria
环境改造对恶性疟原虫和间日疟原虫疟疾发病机制和免疫的影响
- 批准号:
10608071 - 财政年份:2017
- 资助金额:
$ 40.79万 - 项目类别:
Kruppel-Like Factor 2 Counters Vascular and Immunologic Dysfunction in Child Cerebral Malaria
Kruppel 样因子 2 可对抗儿童脑型疟疾的血管和免疫功能障碍
- 批准号:
10084256 - 财政年份:2017
- 资助金额:
$ 40.79万 - 项目类别:
Naturally Acquired Immunity to Malaria during the Epidemiologic Transition in Ken
肯恩流行病学转变期间对疟疾的自然获得免疫力
- 批准号:
8690756 - 财政年份:2011
- 资助金额:
$ 40.79万 - 项目类别:
Naturally Acquired Immunity to Malaria during the Epidemiologic Transition in Ken
肯恩流行病学转变期间对疟疾的自然获得免疫力
- 批准号:
8289398 - 财政年份:2011
- 资助金额:
$ 40.79万 - 项目类别:
Naturally Acquired Immunity to Malaria during the Epidemiologic Transition in Ken
肯恩流行病学转变期间对疟疾的自然获得免疫力
- 批准号:
8146459 - 财政年份:2011
- 资助金额:
$ 40.79万 - 项目类别:
Innate immune factor in host susceptibility to rift valley fever virus
宿主对裂谷热病毒易感性的先天免疫因素
- 批准号:
8234941 - 财政年份:2011
- 资助金额:
$ 40.79万 - 项目类别:
Naturally Acquired Immunity to Malaria during the Epidemiologic Transition in Ken
肯恩流行病学转变期间对疟疾的自然获得免疫力
- 批准号:
8486389 - 财政年份:2011
- 资助金额:
$ 40.79万 - 项目类别:
Naturally Acquired Immunity to Malaria during the Epidemiologic Transition in Ken
肯恩流行病学转变期间对疟疾的自然获得免疫力
- 批准号:
8865541 - 财政年份:2011
- 资助金额:
$ 40.79万 - 项目类别:
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