Solution Properties of Hydrogen-Bonding Polymers and Co-Polymers

9407741平卡斯这项理论研究将在加州大学圣巴巴拉分校和加州大学洛杉矶分校进行。将对由于溶剂分子与链上的运动(例如聚氧化乙烯主链上的氧)之间形成氢键而可溶于水的聚合物进行分析和模拟研究。重点将特别放在氢键的化学性质和与碳氢化合物主干相关的疏水相互作用之间的相互作用上。这些不带电荷的水溶性聚合物在与使用无机溶剂相关的技术问题上有重要的应用，也可以作为一类生物聚合物的活性和功能的模型。这项工作将扩展到其中一部分具有氢键特性而另一部分是更典型的碳氢化合物的共聚物。这类共聚物是药物输送系统中潜在的囊泡稳定剂。这项理论研究将在加州大学圣巴巴拉分校和加州大学洛杉矶分校进行。将对可溶于水的聚合物进行分析和模拟研究。***

9407741 Pincus This theoretical research will be carried out at both the University of California at Santa Barbara and the University of California at Los Angeles. Analytical and simulational investigations will be done on polymers which are soluble in aqueous solvents because of hydrogen bond formation between the solvent molecules and the moities on the chain, e.g., oxygen on the backbone of polyethylene oxide. The particular focus will be on the interplay between the chemical nature of the hydrogen bond and the hydrophobic interaction associated with the hydrocarbon backbone. These uncharged hydrosoluble polymers have important applications to technological issues associated with the use of inorganic solvents and also as models for the activity and function of a class of biopolymers. The work will be extended to copolymers where one part has hydrogen bonding character and the other part is a more typical hydrocarbon. Such copolymers are potential candidates for vesicle stabilizers in drug delivery systems. %%% This theoretical research will be carried out at both the University of California at Santa Barbara and the University of California at Los Angeles. Analytical and simulational investigations will be done on polymers which are soluble in water. ***