RESEARCH INITIATION AWARD: Wear Mechanisms and New Methods of Wear Prevention in Artificial Joints

研究启动奖：人工关节磨损机制和预防磨损新方法

• 批准号: 9410467
• 负责人: Leonard Topoleski
• 金额: $ 9万
• 依托单位: University of Maryland Baltimore County
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-15 至 1998-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9410467&HistoricalAwards=false
• 关键词: RESEARCH; INITIATION; AWARD; Wear; Mechanisms

9410467 Topoleski This Research Initiation Award investigates the fundamental mechanisms of wear in CoCr alloys, a critical step toward improving artificial joint materials and the quality of life for joint recipients, and reducing the cost of arthritis care. Wear is expected to become the major cause of artificial joint failure, requiring costly revision surgery and inducing irreparable bone damage. In order to synthesize new materials, or modify existing materials to resist wear, the fundamental wear mechanisms must be understood. Polyethylene wear is integrally linked to the condition of the articulating metal component, yet research of metal component wear has been practically neglected. Failure analysis of in vivo CoCr wear is an essential element of this research. Surface roughness measurements will provide quantification of wear. Scanning electron microscopy, Auger electron spectroscopy, an x-ray photoelectron spectroscopy will be used to investigate the wear surface. In vitro wear testing to investigate the mechanisms of wear, and the effect of wear surfaces on the integrity of artificial joints will be based on the failure analyses. ***

9410467 Topoleski该研究启动奖调查了CoCr合金磨损的基本机制，这是改善人工关节材料和关节接受者生活质量以及降低关节炎护理成本的关键一步。 预计磨损将成为人工关节失效的主要原因，需要昂贵的翻修手术并引起不可修复的骨损伤。 为了合成新材料，或改进现有材料以抵抗磨损，必须了解基本的磨损机制。 聚乙烯磨损与关节金属部件的状况密切相关，但金属部件磨损的研究实际上被忽视了。 体内钴铬合金磨损失效分析是本研究的重要内容。 表面粗糙度测量将提供磨损的量化。 扫描电子显微镜、俄歇电子能谱、X射线光电子能谱将用于研究磨损表面。 研究磨损机制的体外磨损试验以及磨损表面对人工关节完整性的影响将基于失效分析。 ***