Understanding and controlling neuropeptide GPCR-transducer coupling

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G protein-coupled receptors (GPCRs) are physiologically essential, yet the spatiotemporal complexity of receptor function has limited our understanding of their function and success in drug development. Using a multi-disciplinary approach integrating GPCR signalling, trafficking and drug delivery, this research program aims to understand, and control, the molecular mechanisms that enable a single receptor to respond to different ligands to promote unique cellular processes. The anticipated outcomes include an enhanced capacity for understanding fundamental biology, and stronger national and international collaborations. It will provide significant benefits including expanded basic knowledge and advancement of drug delivery technology.