Understanding and controlling neuropeptide GPCR-transducer coupling

了解和控制神经肽 GPCR-传感器耦合

• 批准号: FT220100617
• 负责人: Dr Nicholas Veldhuis
• 金额: $ 63.48万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-06-18 至 2027-06-17
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100617
• 关键词: Understanding; controlling; neuropeptide; GPCR; transducer

G protein-coupled receptors (GPCRs) are physiologically essential, yet the spatiotemporal complexity of receptor function has limited our understanding of their function and success in drug development. Using a multi-disciplinary approach integrating GPCR signalling, trafficking and drug delivery, this research program aims to understand, and control, the molecular mechanisms that enable a single receptor to respond to different ligands to promote unique cellular processes. The anticipated outcomes include an enhanced capacity for understanding fundamental biology, and stronger national and international collaborations. It will provide significant benefits including expanded basic knowledge and advancement of drug delivery technology.

G蛋白偶联受体(GPCRs)在生理上是必需的，但受体功能的时空复杂性限制了我们对其功能的理解和在药物开发中的成功。这项研究计划采用一种集GPCR信号传递、贩运和药物传递于一体的多学科方法，旨在了解和控制使单个受体对不同配体做出反应的分子机制，以促进独特的细胞过程。预期的结果包括提高理解基础生物学的能力，以及加强国内和国际合作。它将带来巨大的好处，包括扩大基本知识和促进药物输送技术的进步。