Pharmacological modulation of the relaxin-3/RXFP3 neuropeptide system for controlling feeding

用于控制摄食的松弛素 3/RXFP3 神经肽系统的药理学调节

• 批准号: nhmrc : GNT1165801
• 金额: $ 68.92万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pharmacological-modulation-relaxin-controlling-feeding/1379419
• 关键词: Pharmacological; modulation; relaxin; RXFP3; neuropeptide

Eating disorders and addictions are a major health problem worldwide. Relaxin-3 is a neuropeptide transmitter that acts via a single neural receptor to modulate arousal-, stress- and reward-related circuits and resultant behaviours, including feeding. We have produced novel compounds that can effectively inhibit the relaxin-3 receptor signalling and this project will further develop and utilise these in preclinical studies to demonstrate the potential of this receptor as a therapeutic target.

饮食失调和成瘾是全世界的一个主要健康问题。 Relaxin-3 是一种神经肽递质，通过单个神经受体发挥作用，调节与唤醒、压力和奖励相关的回路以及由此产生的行为，包括进食。我们已经生产出可以有效抑制松弛素 3 受体信号传导的新型化合物，该项目将在临床前研究中进一步开发和利用这些化合物，以证明该受体作为治疗靶点的潜力。