Pharmacological modulation of the relaxin-3/RXFP3 neuropeptide system for controlling feeding

饮食失调和成瘾是世界范围内的一个主要健康问题。松弛蛋白-3是一种神经肽递质，它通过单一的神经感受器来调节与唤醒、压力和奖励相关的回路和结果行为，包括进食。我们已经生产出能够有效抑制松弛蛋白-3受体信号的新化合物，该项目将进一步开发和利用这些化合物进行临床前研究，以展示该受体作为治疗靶点的潜力。

Eating disorders and addictions are a major health problem worldwide. Relaxin-3 is a neuropeptide transmitter that acts via a single neural receptor to modulate arousal-, stress- and reward-related circuits and resultant behaviours, including feeding. We have produced novel compounds that can effectively inhibit the relaxin-3 receptor signalling and this project will further develop and utilise these in preclinical studies to demonstrate the potential of this receptor as a therapeutic target.