Oil-Water Interfacial Synthesis as a Benign and Safer Alternative to Conventional Liquid-Phase Syntheses

P.I: P.K. Lim首席研究员将在4月27日至29日在南卡罗来纳州斯帕坦堡举行的“清洁先生”会议上介绍一项由nsf赞助的项目的研究结果。目标是使一种对环境无害的新合成技术在商业上得到采用。这项新的合成技术是基于一项名为“油水界面合成作为传统液相合成的一种良性和更安全的替代品”的研究，该研究由美国国家科学基金会资助。界面反应技术通过使用无害的油水混合物和表面活性催化剂配合物，避免了对有毒或有害溶剂的需要。表面活性配体用于将催化剂吸引到油水界面，在那里催化剂影响反应，也可以在那里回收。新技术与传统的相转移反应技术的不同之处在于，反应发生在界面上，而不是在其中一个体相中。除了对环境无害外，界面合成技术还具有催化剂易于回收、高反应活性和选择性（通常与均相催化有关）以及易于操作等优点。新技术在2,6 -二甲基苯酚偶联聚合上得到了成功的验证。在温和的反应条件下，以高收率（85%）得到了高分子量的聚环氧苯。详细的动力学结果将在会议上公布。

ABSTRACT Proposal Number: CTS-9414672 P.I.: P.K. Lim The principle investigator is presenting the research findings of an NSF-sponsored project at the "Mr. Clean" Conference that is to be held at Spartanburg, SC on April 27-29. The goal is to effect the commercial adoption of a new synthesis technique that is environmentally benign. The new synthesis technique is based on research, entitled "Oil-Water Interfacial Synthesis as a Benign and Safer Alternative to Conventional Liquid-Phase Syntheses," that has been funded by the NSF. The interfacial reaction technique avoids the need for toxic or hazardous solvents by using an innocuous oil-water mixture in conjunction with a surface-active catalyst complex. A surface-active ligand is used to draw the catalyst to the oil-water interface, where the catalyst effects the reaction and where it can also be recovered. The new technique differs from conventional phase-transfer reaction technique in that the reaction occurs at the interface, rather than in one of the bulk phases. Aside from being environmentally benign, the interfacial synthesis technique also offers the advantages of easy catalyst recovery, high reactivity and selectivity that is normally associated with homogenous catalysis, and ease of operation. The new technique has been successfully demonstrated on the coupling polymerization of 2, 6-dimethylphenol. high molecular-weight poly (phenylene oxide) has been obtained in a high yield (85%) under mild reaction conditions. Detailed kinetic results will be presented at the conference.