Redefining how T cell recognition drives T cell activation

重新定义 T 细胞识别如何驱动 T 细胞激活

• 批准号: DE230101012
• 负责人: Dr Pirooz Zareie
• 金额: $ 33.17万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101012
• 关键词: Redefining; how; cell; recognition; drives

This proposal aims to define the key mechanisms that determine how T cells recognise and respond to foreign antigens; a critical feature that defines effective immunity. To achieve this goal, this proposal will leverage multidisciplinary collaborations and innovative methods to understand how structural and biochemical features of T cell receptor recognition influences T cell mediated immunity and development. In turn, this project will facilitate further research and development in the burgeoning field of T cell biology and advance life science research in Australia. Furthermore, as T cell biology is relevant to all vertebrates, this research will greatly benefit the conservation of threatened animal species and agriculture.

这项提议旨在定义决定T细胞如何识别和响应外来抗原的关键机制；这是定义有效免疫的关键特征。为了实现这一目标，该建议将利用多学科合作和创新方法来了解T细胞受体识别的结构和生化特征如何影响T细胞介导的免疫和发育。反过来，该项目将促进在新兴的T细胞生物学领域的进一步研究和开发，并促进澳大利亚的生命科学研究。此外，由于T细胞生物学与所有脊椎动物相关，因此这项研究将极大地有助于濒危动物物种的保护和农业。