A Dual Plasma Binding Protein System for Thyroid Hormone and Vitamin D

甲状腺激素和维生素 D 的双血浆结合蛋白系统

• 批准号: 9419310
• 负责人: Paul Licht
• 金额: $ 24.8万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9419310&HistoricalAwards=false
• 关键词: Dual; Plasma; Binding; Protein; System

9419310 Licht This project will examine the molecular biology and physiology of an unusual dual-function blood binding protein. Based on preliminary data, this protein has structural similarity to vitamin-D-binding protein (VDBP), but Dr. Licht has determined that it also serves as a high affinity thyroid hormone binding protein (TBP); normally these two hormones are transported by very different types of protein. He will attempt to identify the structural features that permit this mixed function and study how the synthesis of the binding protein in the liver is regulated by hormones in order to test the hypothesis that it may be involved in the thyroidal regulation of growth or vitamin D utilization. ***

9419310 Licht 该项目将研究一种不寻常的双功能血液结合蛋白的分子生物学和生理学。 根据初步数据，该蛋白与维生素 D 结合蛋白 (VDBP) 结构相似，但 Licht 博士确定它也可作为高亲和力甲状腺激素结合蛋白 (TBP)；通常，这两种激素由非常不同类型的蛋白质运输。 他将尝试确定允许这种混合功能的结构特征，并研究肝脏中结合蛋白的合成如何受激素调节，以检验它可能参与甲状腺生长调节或维生素 D 利用的假设。 ***