A Dual Plasma Binding Protein System for Thyroid Hormone and Vitamin D

小行星9419310 这个项目将研究一种不寻常的双功能血液结合蛋白的分子生物学和生理学。 根据初步数据，这种蛋白质与维生素D结合蛋白（VDBP）具有结构相似性，但Licht博士确定它也是一种高亲和力的甲状腺激素结合蛋白（TBP）;通常这两种激素由非常不同类型的蛋白质运输。 他将试图确定允许这种混合功能的结构特征，并研究肝脏中结合蛋白的合成如何受到激素的调节，以检验它可能参与甲状腺生长或维生素D利用的调节的假设。 ***

9419310 Licht This project will examine the molecular biology and physiology of an unusual dual-function blood binding protein. Based on preliminary data, this protein has structural similarity to vitamin-D-binding protein (VDBP), but Dr. Licht has determined that it also serves as a high affinity thyroid hormone binding protein (TBP); normally these two hormones are transported by very different types of protein. He will attempt to identify the structural features that permit this mixed function and study how the synthesis of the binding protein in the liver is regulated by hormones in order to test the hypothesis that it may be involved in the thyroidal regulation of growth or vitamin D utilization. ***