Comparative Physiology of Pituitary Hormones: Regulation o Secretion

垂体激素的比较生理学：分泌调节

• 批准号: 9020493
• 负责人: Paul Licht
• 金额: $ 39万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-15 至 1995-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9020493&HistoricalAwards=false
• 关键词: Comparative; Physiology; Pituitary; Hormones; Regulation

This project will take advantage of unique aspects of the hypothalamic-pituitary system in a common species of turtle (Pseudemys scripta) and frog (Rana pipiens) to study the dynamic relationship between brain peptide regulation of pituitary function and its modulation by peripheral feedback in relation to gonadal and thyroidal function. The turtle pituitary model will be used to study responsiveness of TSH secretion and environmental regulation of TSH secretion with emphasis on plasma binding proteins. Thyroxine binding protein will be purified and characterized for studies on its physiological role in the regulation of thyroid hormone transport and function in hopes of developing a model for understanding the evolution and function of thyroxine binding globulins. The demonstrated resistance of the frog pituitary to desensitization by gonadotropin-releasing hormone (GnRH) will be exploited to study the action of this neuropeptide on gonadotropin biosynthesis and its modulation by steroids. Parallel measurements of GnFH in the hypothalamus willl seek to determine how steroids influence pituitary regulation by actions in the brain.//

这个项目将利用独特的方面， 常见龟类下丘脑-垂体系统 （Pseudemys scripta）和蛙（Rana pipiens）进行动态研究 脑肽与垂体调节的关系 功能及其通过外周反馈的调节， 性腺和甲状腺功能。 海龟脑垂体模型将 用于研究TSH分泌的反应性， 促甲状腺激素分泌的环境调节，重点是血浆 结合蛋白 将纯化甲状腺素结合蛋白， 其特征在于研究其生理作用， 调节甲状腺激素的转运和功能， 开发一个模型来理解 甲状腺素结合球蛋白。 所表现出的抵抗力 蛙脑垂体对促性腺激素释放脱敏作用 促性腺激素释放激素（GnRH）将被用来研究这一行动 神经肽对促性腺激素生物合成的调节作用 类固醇. 下丘脑中GnFH的平行测量 将试图确定类固醇如何影响垂体 通过大脑中的行为进行调节。