A cAMP-Regulated RNA-Binding Protein that Interacts with PEPCK mRNA

一种与 PEPCK mRNA 相互作用的 cAMP 调节的 RNA 结合蛋白

• 批准号: 9420733
• 负责人: Yaacov Hod
• 金额: $ 27.8万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-03-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9420733&HistoricalAwards=false
• 关键词: cAMP; Regulated; RNA; Binding; Protein

; R o o t E n t r y F h C o m p O b j b W o r d D o c u m e n t O b j e c t P o o l F Microsoft Word 6.0 Document MSWordDoc Word.Document.6 ; Oh +' 0 $ H l D h R:\WWUSER\TEMPLATE\NORMAL.DOT 9420733 marcia steinberg marcia steinberg @ Pt @ @ Pt @ Microsoft Word 6.0 2 ; S u m m a r y I n f o r m a t i o n ( F u c u D c ` c h ^ ` c ` c V c u D C c G C c u D C c c ' ' ' ' , 0 , K @ Normal a c " A@ " Default Paragraph Font . @ . TOC 1 0 , (# $ , @ , TOC 2 0 , (# $ , @ , TOC 3 p 0 , (# $ , @ , TOC 4 @ 0 , (# $ , @ , TOC 5 0 , (# $ ( @ ( TOC 6 0 , (# $ @ TOC 7 0 , ( @ ( TOC 8 0 , (# $ ( @ ( TOC 9 0 , (# $ . @ . Index 1 ` , (# $ . @ . Index 2 0 , (# $ ( .@ ( TOA Heading , (# $ "@ Caption c O _Equation Caption ! F b marcia steinberg \\CLM11\MCBPUB\BIOCHEM\HOD.WP5 marcia steinberg \\CLM11\MCBPUB\BIOCHEM\HOD.ABS @HP DeskJet 500 LPT1: HPDSKJET HP DeskJet 500 D L f , , # N }w; } d g 2 HP DeskJet 500 D L f , , # N }w; } d g 2 C Times New Roman Symbol & Arial 5 Courier New 9 ) e e "; 9420733 marcia steinberg marcia steinberg ; in and study its physiological role. *** ; e 3 e C | ~ ~ ~ , T q ; | | b 9420733 PRIVATE Hod. The broad goal of this project is to characterize the recently identified cAMP regulated RNA binding protein (RBP) that interacts with PEPCK mRNA (Nachaliel, N., Jain, D., and Hod, Y., 1993, J. Biol. Chem. 268, 24203). Several features of the RBP suggest that it may play an important physiological role. The activity of the RBP, which is most abundant in the cytosolic fraction, was found to be significantly reduced in rat hepatoma cells treated with cAMP, or in livers of starved rats, a physiological state associated with an increased level of

;​R o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o​F Microsoft Word 6.0文档MSWordDoc。6;Oh +' 0 $ H l D H R:\WWUSER\TEMPLATE\NORMAL。marcia steinberg @ Pt @ Pt @ Microsoft Word 6.0 2;如果我是你，我是你，我是你，我是你，我是你。F (c) u (D) c (c) h (c) c (V) u (D) c (c) c (G) c (uD C C C ' ' ‘ ’， 0, K @ Normal a c“a @”默认段落字体。@。TOC 1 0, (# $, @, TOC 2 0, (# $, @, TOC 3 0, (# $, @, TOC 4 @ 0, (# $, @, TOC 5 0, (# $ (@) (TOC 6 0, (# $ @ TOC 7 0, (@ (TOC 8 0, (# $ （@) TOC 9 0, (# $)）@。索引1 ',(# $。@。索引0，（# $）@ （TOA标题，）# $ "@标题c O _Equation标题！F b marcia steinberg \\CLM11\MCBPUB\BIOCHEM\HOD。WP5 marcia steinberg \\CLM11\MCBPUB\BIOCHEM\HOD。ABS @HP DeskJet 500 LPT1: HPDSKJET HP DeskJet 500 D L f,, # N}w；} d g 2 HP DeskJet 500 d L f,, # N}w；} d g 2 C Times New Roman Symbol & Arial 5 Courier New 9) e "；9420733 Marcia steinberg；研究其生理作用。*** ;e 3 e C | ~ ~ ~，tq；| | b 9420733 PRIVATE Hod。本项目的主要目标是表征最近发现的cAMP调控的RNA结合蛋白（RBP）与PEPCK mRNA相互作用（Nachaliel， N., Jain， D., and Hod， Y., 1993， J. Biol.）。化学，268,24203)。RBP的几个特征表明它可能起着重要的生理作用。RBP的活性在细胞质部分最为丰富，在经cAMP处理的大鼠肝癌细胞或饥饿大鼠的肝脏中，RBP的活性被发现显著降低，这种生理状态与RBP水平的增加有关