ASBMB Fall Symposium "Mechanisms of Regulated Intracellular Protein Degradation, to be held October 14-17, 1994, in Whistler, British Columbia, CANADA

由美国生物化学和分子生物学学会（ASBMB）主办的关于细胞内蛋白降解调控机制的研讨会将于1994年10月14日至17日在加拿大不列颠哥伦比亚省惠斯勒举行。200至250名科学家（包括演讲者和主持人）将根据他们在该领域的专业知识和兴趣以及他们对该科学计划成功的预期贡献进行选择。真核生物胞内蛋白降解是一个复杂的过程，涉及多个系统和途径。在某种程度上，这反映了必须由细胞影响的各种类型的转换。一些机制显然是高度调控的，涉及特定蛋白质和酶以精心编程的方式的周转，而其他机制更普遍地响应蛋白质类别，如内化配体或错误折叠或损坏的蛋白质。例如，与合成过程相比，对所涉及的蛋白酶或识别其潜在底物的信号所知相对较少。本次会议将重点关注蛋白质结构中被认为在一般和程序性蛋白质周转的调节中起关键作用的元素，以及可能参与其中的蛋白酶。演讲和讨论的范围将从评估单个组成部分的结构和功能关系到已知涉及程序性周转的生理相关反应。各种实验室的最新进展表明，这是一个特别好的时机来分析我们目前对蛋白质降解信号和机制的理解，并评估未来的方向。这次关于调节细胞内蛋白质降解机制的会议将成为激发科学家兴趣的催化剂，这些科学家可能已经掌握了解决这些问题的工具，并将重点放在那些尚未开始独立研究主要领域的年轻科学家身上。＊＊＊

Bradshaw 9420919 A Symposium on Mechanisms of Regulated Intracellular Protein Degradation will be held under the auspices of the American Society for Biochemistry and Molecular Biology (ASBMB) on October 14 -17, 1994, in Whistler, British Columbia, CANADA. Participation will be 200 to 250 scientists (including speakers and moderators), selected on the basis of their expertise and interest in this area, and their expected contribution to the success of this scientific program. Intracellular protein degradation in eukaryotes is clearly a complex process involving multiple systems and pathways. In part, this reflects the various types of turnover that must be effected by cells. Some mechanisms are clearly highly regulated and involve the turnover of the specific proteins and enzymes in a carefully programmed fashion, whereas other mechanisms respond more generally to classes of proteins such as internalized ligands or incorrectly folded or damaged proteins. As compared, for example, to synthetic processes, relatively little is known about either the proteases involved or the signals that identify their prospective substrates. This meeting will focus on the elements in protein structure that are thought to play key roles in the regulation of both general and programmed protein turnover and the proteases that are likely to be involved. The presentations and discussions will range from evaluations of the structure and functional relationships of individual components to physiologically relevant responses that are known to involve programmed turnover. Recent advances from a variety of laboratories indicate that this is a particularly good time for an analysis of our current understanding of protein degradation signals and mechanisms and to evaluate future directions. %%% This meeting on Mechanisms of Regulated Intracellular Protein Degradation will serve as a catalyst for stimulating the interest of scientists who may already have the tools in hand to approach these problems with a focus on those young scientists who are yet to initiate a major area of independent research. ***