Molecular Biology of Circadian Oscillations in Drosophila

果蝇昼夜节律振荡的分子生物学

基本信息

  • 批准号:
    9421475
  • 负责人:
  • 金额:
    $ 31.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    1995
  • 资助国家:
    美国
  • 起止时间:
    1995-02-01 至 1998-07-31
  • 项目状态:
    已结题

项目摘要

9421475 Organisms as diverse as fungi, flies, and humans exhibit circadian rhythms, daily rhythms in physiology and behavior that are generated and coordinated by an internal timekeeping system, referred to as a 'circadian clock'. Circadian clocks in virtually all organisms examined to date share certain fundamental properties. These include an intrinsic rhythm that is slightly different than the natural 24-hour day, the exact value depending on the species, the ability to synchronize to the natural day by exposure to light-dark cycles, and a highly-regular rhythmicity that does not change in rate at different temperatures, unlike simple chemical reactions. The genetic and biochemical basis of the circadian clock is only poorly understood, despite its importance in organizing physiology and behavior in humans and other organisms. The most sophisticated information to date has been obtained from genetic studies in the fruitfly Drosophila melanogaster, which have led to the cloning and characterization of a circadian clock gene called period. Recent genetic and biochemical experiments have confirmed that the protein product of the period gene is a key component of the circadian clock. Accumulating evidence suggests that the 'works' of the clock consist of a precisely-timed oscillation in the abundance of the period protein. This molecular rhythm results from a highly-regulated rhythmic synthesis of the period protein, a process in which the period protein itself and at least several as-yet uncharacterized proteins are involved. The objective of these investigations is to identify novel proteins that play a role in the genesis or regulation of circadian oscillations. The strategy being employed is to identify the as-yet uncharacterized proteins that interact with the period protein and which are involved in regulating its biological activity. The long-range goal is to understand quantitatively how a small set of genes and their protein products can form a precise, self-sustaining d aily timing mechanism.
9421475 真菌、苍蝇和人类等多种生物体都表现出昼夜节律,即生理和行为上的每日节律,这些节律是由内部计时系统(称为“昼夜节律钟”)产生和协调的。 迄今为止,几乎所有生物体的昼夜节律钟都具有某些基本特性。 这些包括与自然24小时略有不同的内在节律,取决于物种的确切值,通过暴露于光暗周期与自然日同步的能力,以及在不同温度下不会改变速率的高度规则的节律性,不像简单的化学反应。 生物钟的遗传和生化基础知之甚少,尽管它在组织人类和其他生物的生理和行为方面很重要。 迄今为止,最复杂的信息是从果蝇的遗传研究中获得的,这些研究导致了一种称为周期的生物钟基因的克隆和表征。 最近的遗传学和生物化学实验已经证实,周期基因的蛋白质产物是生物钟的关键组成部分。 越来越多的证据表明,生物钟的“工作”包括周期蛋白丰度的精确定时振荡。 这种分子节律是由周期蛋白的高度调节的节律性合成引起的,这一过程涉及周期蛋白本身和至少几种尚未表征的蛋白质。 这些研究的目的是鉴定在昼夜节律振荡的发生或调节中起作用的新蛋白质。 所采用的策略是识别与周期蛋白相互作用并参与调节其生物活性的尚未表征的蛋白质。 长期目标是定量地了解一小部分基因及其蛋白质产物如何形成精确的、自我维持的DNA定时机制。

项目成果

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Charles Weitz其他文献

Charles Weitz的其他文献

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{{ truncateString('Charles Weitz', 18)}}的其他基金

Dissertation Research: Dermatoglyphic Analysis of Discordant Male Monozygotic Twins
论文研究:不一致的男性同卵双胞胎的皮纹分析
  • 批准号:
    9514175
  • 财政年份:
    1996
  • 资助金额:
    $ 31.4万
  • 项目类别:
    Standard Grant
High Altitude Research in Quinghai, China
中国青海高海拔研究
  • 批准号:
    9018805
  • 财政年份:
    1990
  • 资助金额:
    $ 31.4万
  • 项目类别:
    Standard Grant
Sfc Travel Support (In Indian Currency) to Participate in The Golden Jubilee Conference on Human Genetics and Adaptation, Calcutta, February 1-5, 1982
证监会为参加 1982 年 2 月 1 日至 5 日加尔各答人类遗传学与适应金禧会议提供差旅支持(以印度货币计算)
  • 批准号:
    8120706
  • 财政年份:
    1982
  • 资助金额:
    $ 31.4万
  • 项目类别:
    Standard Grant
Travel to Prepare a Proposal For Joint Rsch. With Dept's Of Archaeology & Geography at University of Peshawar; Peshawar, Pakistan; January 13 - February 8, 1981
前往准备联合 Rsch 提案。
  • 批准号:
    8100598
  • 财政年份:
    1981
  • 资助金额:
    $ 31.4万
  • 项目类别:
    Standard Grant

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Journal of Integrative Plant Biology
  • 批准号:
    31024801
  • 批准年份:
    2010
  • 资助金额:
    24.0 万元
  • 项目类别:
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Dinoflagellate Molecular Biology and Mecanisms of Circadian Rhythms
甲藻分子生物学和昼夜节律机制
  • 批准号:
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  • 财政年份:
    2017
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  • 批准号:
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  • 财政年份:
    2015
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    2014
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Dinoflagellate Molecular Biology and Mecanisms of Circadian Rhythms
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  • 批准号:
    171382-2013
  • 财政年份:
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MOLECULAR BIOLOGY OF THE MAMMALIAN CIRCADIAN CLOCK
哺乳动物昼夜节律的分子生物学
  • 批准号:
    2252026
  • 财政年份:
    1995
  • 资助金额:
    $ 31.4万
  • 项目类别:
MOLECULAR BIOLOGY OF THE MAMMALIAN CIRCADIAN CLOCK
哺乳动物昼夜节律的分子生物学
  • 批准号:
    2252025
  • 财政年份:
    1995
  • 资助金额:
    $ 31.4万
  • 项目类别:
Molecular Biology of a Neuronal Circadian Oscillator
神经元昼夜节律振荡器的分子生物学
  • 批准号:
    9010115
  • 财政年份:
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MOLECULAR BIOLOGY OF CIRCADIAN RHYTHMS IN DROSOPHILA
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  • 批准号:
    3025809
  • 财政年份:
    1989
  • 资助金额:
    $ 31.4万
  • 项目类别:
MOLECULAR BIOLOGY OF CIRCADIAN RHYTHMS IN DROSOPHILA
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  • 批准号:
    3025808
  • 财政年份:
    1988
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  • 项目类别:
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