Discovering new high-risk ovarian cancer predisposing genes through targeted genetic analyses of a Canadian founder population

通过对加拿大创始人群进行有针对性的遗传分析，发现新的高风险卵巢癌易感基因

• 批准号: 370298
• 负责人: Tonin Patricia N
• 金额: $ 49.6万
• 依托单位: Research Institute of the McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=370298&lang=en
• 关键词: Biobanks; Cancer Predispositon; Cancer Prevention; Dna Sequencing; Exome Sequencing; Founder Populations; Germline Mutations,; Hereditary Cancer,; Mutation Screening; Ovarian Cancer

Since the discovery of the BRCA1 and BRCA2 genes over 20 years ago, research has shown that carriers of mutations in these genes significantly increases their risk for ovarian cancer. Cancer prevention studies have since shown that the removal of ovaries

自20多年前发现BRCA1和BRCA2基因以来，研究表明这些基因突变的携带者显着增加了患卵巢癌的风险。癌症预防研究表明，切除卵巢