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An integrated functional and genomics approach at elucidating the chromosome 3 genes important in ovarian cancer

An integrated functional and genomics approach at elucidating the chromosome 3 genes important in ovarian cancer
综合功能和基因组学方法阐明卵巢癌中重要的 3 号染色体基因
批准号：
187561
负责人：
Tonin Patricia N
金额：
$7.29万
依托单位：
Research Institute of the McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-03-01 至 2010-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=187561&lang=en
关键词：
Chromosome/Gene Transfer Gene Expression Arrays Mutation Analysis Ovarian Cancer Positonal Cloning Tumor Suppressor Genes

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Ovarian cancer remains an important health problem for women. The Canadian Cancer Statistics estimate 2,500 new cases and 1,500 deaths will be reported per annum in Canada. Ovarian cancer has the highest fatality rate of any gynecologic cancer and is the
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Interrogating large available biobank data from defined cohorts to investigate a moderately infrequent, functionally aberrant and potentially actionable proposed new cancer predisposing alleles.
Discovering new high-risk ovarian cancer predisposing genes through targeted genetic analyses of a Canadian founder population
Elucidating the tumor suppressor genes involved in reprogramming an ovarian cancer cell line model modified by chromosome 3 transfer
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