Innovation in the Undergraduate Chemistry Curriculum through Integration of FT-NMR Spectroscopy

[452027]英国现代核磁共振原理和实践已被纳入化学课程的上下级课程。讲座和实验室的创新不仅影响了化学系的专业，也影响了生物学和专业预科课程的学生。该部门正在将一台200兆赫的傅立叶变换核磁共振光谱仪与位于新设计的科学大楼的新型实验室/计算机工作站环境中的个人计算机联网，以实现实时光谱处理和讨论。课程的改变始于二年级的有机化学课程：在第一门课程的早期就引入了核磁共振波谱学，并且用宽带解耦13C光谱和13C DEPT光谱来说明同分异构、命名、反应和反应机理的课堂讨论。1H-NMR通过HETCOR光谱与13C结合。在有机实验室中，学生有机会生成他们产品的13C和DEPT或HETCOR光谱，补充了这些光谱在课堂上的使用。该仪器还用于说明有机反应中的旋转同分异构、立体选择性和区域选择性等现象。在大三，无机化学专业的学生合成了一个配体并创造了一个新的配合物，然后利用变温核磁共振减缓了可逆络合的快速交换动力学，并确定了一个配合物的解离常数。生物化学序列的高年级学生获得并解释神经肽的COSY和NOESY光谱，确定各种化学环境下肽的二级结构特征。在物理化学中，这些学生利用核磁共振观察溶剂对分子构象的影响，并对构象变化进行热力学分析。该仪器在定向研究（本科研究）课程中得到额外使用；研究项目在无机，物理和生物化学是可用的。

9452027 Brittain Modern NMR principles and practice are being integrated into both lower- and upper-level courses in the chemistry curriculum. The innovations in the lecture and laboratory affect not only the department's chemistry majors, but also students enrolled in the biology and pre-professional programs. The department is networking a 200 MHz Fourier transform NMR spectrometer with broadband and variable temperature capabilities to personal computers located in a novel laboratory/computer-workstation environment in a newly designed science building to permit real-time spectral processing and discussion. The curricular changes begin in the sophomore organic chemistry sequence: NMR spectroscopy is being introduced early in the first course, and lecture discussions of isomerism, nomenclature, reactions and reaction mechanisms are illustrated with broadband-decoupled 13C spectra and 13C DEPT spectra. 1H-NMR is integrated with 13C through HETCOR spectroscopy. In the organic laboratory, the opportunity for students to generate 13C and DEPT or HETCOR spectra of their products complements the use of these spectra in lecture. The instrument also is used to illustrate phenomena such as rotational isomerism and stereo- and regioselectivity in organic reactions. In the junior year, students enrolled in Inorganic Chemistry synthesize a ligand and create a new complex, then utilize variable temperature NMR to slow the fast-exchange dynamics of reversible complexation and determine a complex dissociation constant. Senior students in the biochemistry sequence obtain and interpret COSY and NOESY spectra of neuropeptides, determining peptide secondary structural features in various chemical environments. In physical chemistry, these students utilize NMR to observe the effect of solvent on molecular conformation and perform a thermodynamic analysis of the conformational change. The instrument receives additional usage in directed studies (undergraduate research) cou rses; research projects in inorganic, physical, and biochemistry are available.