Innovation in the Undergraduate Chemistry Curriculum through Integration of FT-NMR Spectroscopy

9452027 Brittain现代核磁共振原理和实践正在被整合到化学课程中的低级和高级课程中。在讲座和实验室的创新不仅影响部门的化学专业，而且在生物学和预科课程就读的学生。 该部门正在联网的200兆赫傅里叶变换核磁共振光谱仪与宽带和可变温度的能力，位于一个新设计的科学大楼，允许实时光谱处理和讨论的新的实验室/计算机工作站环境的个人计算机。 课程的变化开始在大二有机化学序列：NMR光谱学被引入早期的第一门课程，和讲座讨论的异构，命名，反应和反应机理说明与宽带去耦13 C光谱和13 C DEPT光谱。 1H-NMR通过HETCOR光谱与13 C整合。 在有机实验室中，学生有机会生成其产品的13 C和DEPT或HETCOR光谱，补充了这些光谱在讲座中的使用。 该仪器还用于说明有机反应中的旋转异构现象和立体选择性和区域选择性。 在大三，学生就读于无机化学合成配体，并创建一个新的复合物，然后利用变温核磁共振减慢可逆络合的快速交换动力学，并确定一个复杂的解离常数。 生物化学序列中的高年级学生获得并解释神经肽的COSY和NOESY光谱，确定各种化学环境中肽的二级结构特征。 在物理化学中，这些学生利用NMR观察溶剂对分子构象的影响，并对构象变化进行热力学分析。 该仪器在定向研究（本科研究）课程中得到额外的使用;无机，物理和生物化学的研究项目可用。

9452027 Brittain Modern NMR principles and practice are being integrated into both lower- and upper-level courses in the chemistry curriculum. The innovations in the lecture and laboratory affect not only the department's chemistry majors, but also students enrolled in the biology and pre-professional programs. The department is networking a 200 MHz Fourier transform NMR spectrometer with broadband and variable temperature capabilities to personal computers located in a novel laboratory/computer-workstation environment in a newly designed science building to permit real-time spectral processing and discussion. The curricular changes begin in the sophomore organic chemistry sequence: NMR spectroscopy is being introduced early in the first course, and lecture discussions of isomerism, nomenclature, reactions and reaction mechanisms are illustrated with broadband-decoupled 13C spectra and 13C DEPT spectra. 1H-NMR is integrated with 13C through HETCOR spectroscopy. In the organic laboratory, the opportunity for students to generate 13C and DEPT or HETCOR spectra of their products complements the use of these spectra in lecture. The instrument also is used to illustrate phenomena such as rotational isomerism and stereo- and regioselectivity in organic reactions. In the junior year, students enrolled in Inorganic Chemistry synthesize a ligand and create a new complex, then utilize variable temperature NMR to slow the fast-exchange dynamics of reversible complexation and determine a complex dissociation constant. Senior students in the biochemistry sequence obtain and interpret COSY and NOESY spectra of neuropeptides, determining peptide secondary structural features in various chemical environments. In physical chemistry, these students utilize NMR to observe the effect of solvent on molecular conformation and perform a thermodynamic analysis of the conformational change. The instrument receives additional usage in directed studies (undergraduate research) cou rses; research projects in inorganic, physical, and biochemistry are available.