A Bio-Electrical, Stress-Responsive Composite Coating for Prostheses

用于假肢的生物电、应力响应复合涂层

• 批准号: 9460179
• 负责人: Douglas Miller
• 金额: $ 6.5万
• 依托单位: Lynntech Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-01-01 至 1995-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9460179&HistoricalAwards=false
• 关键词: Bio; Electrical; Stress; Responsive; Composite

Hundreds of thousands of orthopedic implantations are performed each year in the U.S., yet failure rates of these replacements remain significant. Second generation cementless prostheses, the hopeful alternative to poly-methylmethacrylate fixation, have not fulfilled their promise of long term stability. The cause remains essentially the same: differential stress at the bone-implant interface which impairs osteointegration and results in the formation of particulate debris and the reactive formation of poorly defined and mechanically unstable fibrous tissue. Lynntech, Inc., proposes to develop a bioelectronic coating for porous prostheses which combines the osteoconductive properties of a biological matrix with a piezoelectric polymer (polyvinylidene difluoride) that has proven osteoinductive capability. It is anticipated that this combination will not only lead to improved initial osteointegration of implants, but that PVDF, being bioinert, will remain associated with newly formed tissue at the bone-implant interface. Being permanently piezoelectric, it may then provide the basis for response to changes in stress at this interface by electrically stimulating further bone remodeling. The result would be a prosthetic surface capable of active response to a dynamic environment, thus decreasing failure rates.

在美国，每年进行数十万例矫形手术，然而，这些更换的失败率仍然很高。第二代非骨水泥假体，有望替代聚甲基丙烯酸甲酯固定，但尚未实现其长期稳定性的承诺。原因基本相同：骨-植入物界面的应力差，这会损害骨整合并导致颗粒碎片形成以及反应性形成边界不清和机械不稳定的纤维组织。Lynntech，Inc.，提出开发一种用于多孔假体的生物电子涂层，其将生物基质的骨传导性质与已证明具有骨诱导能力的压电聚合物（聚偏二氟乙烯）相结合。预计这种组合不仅会改善植入物的初始骨整合，而且生物惰性的PVDF将保持与骨-植入物界面处新形成的组织相结合。由于永久压电，因此可以通过电刺激进一步的骨重建来提供对该界面处的应力变化的响应的基础。其结果将是假体表面能够对动态环境做出主动响应，从而降低故障率。