SN2 Type Glycosylation

本研究的重点是开发有效的方法来制备功能化的硫代糖苷和磷酸糖苷，并将这些糖苷用于低聚糖的非对映选择性合成。教育计划的重点是开发项目、实验室和小组活动，将学习培养为一种主动而不是被动的活动。将强调协作学习。通过这一职业奖项，合成有机计划支持纽约大学化学系赵康博士的研究和教育计划。赵教授将专注于开发一种自动化方案，允许将各种反应性调节的糖基供体与固体载体上的受体偶联。赵教授的教育计划的重点是开发项目、实验室和小组活动，将学习培养为一种主动而不是被动的活动。将强调协作学习。

The focus of this research is the development of efficient methods for the preparation of functionalized thio- and phosphoglycosides and to use these glycosides for diastereoselective synthesis of oligosaccharides. The focus of the educational plan involves the development of programs, laboratories and group activities that foster learning as an active rather than passive activity. Collaborative learning will be stressed. With this CAREER award, the Synthetic Organic Program is supporting the research and educational plan of Dr. Kang Zhao of the Department of Chemistry at New York University. Professor Zhao will focus his research efforts on the development of an automated protocol that allows the coupling of a variety of reactivity- modulated glycosyl donors with acceptors on solid supports. The focus of Professor Zhao's educational plan involves the development of programs laboratories and group activities that foster learning as an active rather than passive activity. Collaborative learning will be stressed.