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Symposium on RNA Biology: RNA-Protein Interaction on October 13-15, 1995 at Research Triangle Park, North Carolina

Symposium on RNA Biology: RNA-Protein Interaction on October 13-15, 1995 at Research Triangle Park, North Carolina
RNA 生物学研讨会:RNA-蛋白质相互作用,1995 年 10 月 13-15 日在北卡罗来纳州三角研究园举行
批准号:
9502254
负责人:
Paul Agris
金额:
$0.3万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
1995
资助国家:
美国
项目状态:
已结题
起止时间:
1995-04-01 至 1996-03-31

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项目成果

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中文摘要
翻译
;​R o o t E n t y F K 6 C o m p o b j b W o r d d o c u m e n t O b j e c t P O O l ' 6尺69:;= ?@ A B F Microsoft Word 6.0文档MSWordDoc6;​^ doj oPj R v SQW K F o o o o o ~ t 2j o o ~ u ~ t N 3 j j F v = u;农业RNA的合成、化学、结构和功能对所有生物系统的生存能力至关重要,因此对农业、医学和环境研究具有重要意义。这一研究促进了RNA作为靶标和试剂的生物技术应用。尽管第一个RNA结构在大约20年前就被解决了,但直到现在,我们才开始通过结合使用x射线晶体学,核磁共振,生化,分子生物学和遗传学方法来了解RNA与蛋白质的相互作用。新的和令人兴奋的RNA结构已经被发现,并揭示了与蛋白质相互作用的有趣的新功能模式。然而,没有一个会议专门关注RNA蛋白质相互作用的主题,以创造一个知识交流的环境和一个分享数据和技术的论坛。许多不同的研究小组正在使用各种方法来了解RNA的可塑性以及RNA结构是如何被蛋白质识别的。因此,召开RNA -蛋白质相互作用研讨会是及时的。七名主要研究人员(六名来自美国,一名来自欧洲)已经接受邀请,将于1995年10月13日至15日在北卡罗来纳研究三角举行的研讨会上发言。已经获得了几乎相当于会议估计费用一半的资金。该提案要求国家科学基金会为一名主要演讲者和三名年轻研究人员提供津贴。所要求的资金约占估计总预算的10%。RNA的合成、化学、结构和功能对所有生物系统的生存能力至关重要,因此对农业、医学和环境研究至关重要。这一研究促进了RNA作为靶标和试剂的生物技术应用。新的和令人兴奋的RNA结构已经被发现,并揭示了与蛋白质相互作用的有趣的新功能模式。然而,没有一个会议专门关注RNA蛋白质相互作用的主题,以创造一个知识交流的环境和一个分享数据和技术的论坛。该提案为一名主要发言人和三名年轻研究人员提供津贴。*** ;;@ ....()() ()() ()() () Z:凤凰B L s A;如果你是我,我是你,我是你,我是你,我是你,我是你Oh +' 0 $ H l D H R:\WWUSER\TEMPLATE\NORMAL。DOT杰克科恩杰克科恩@ A @ @ 5 @微软Word 6.0 2e = e " " " " " " " L L L L L L L L L Lh x | | | | | | | \ r T (" | | | | | | " " | x | | | | " | " | 6 " " " " | | 0 |私人农业RNA合成,化学,结构
英文摘要
; R o o t E n t r y F K 6 C o m p O b j b W o r d D o c u m e n t O b j e c t P o o l ' 6 ' 6 9 : ; = ? @ A B F Microsoft Word 6.0 Document MSWordDoc Word.Document.6 ; ^ do foj oPj R v SQW K F ho o o o ~ t 2j t u ~ u ~ t N 3 j j F V = u ; t, j j F V 6 j 6Rj + Bj+ v N ~o o F V o o F V o F 6Rj +~ +Bj ~ u ~ t o u 9 ot tI ^ F V ~o o N 9502254 PRIVATE Agris RNA synthesis, chemistry, structure and function are central to the viability of all biological systems and thus, are important to agricultural, medical and environmental research. This research has led to biotechnological applications of RNA as both target and reagent. Even though the first RNA structure was resolved some twenty years ago, only now are we beginning to understand RNA interaction with proteins through combined use of x ray crystallography, NMR, biochemical, molecular biological and genetic approaches. New and exciting RNA structures have been discovered and are revealing interesting new functional modes of interaction with proteins. However, no meetings have focused exclusively on the topic of RNA protein interactions to create an environment of intellectual exchange and a forum to share data and techniques. Many different groups are using a variety of approaches to understand the plasticity of RNA and how RNA structure is recognized by proteins. Thus, a Symposium on RNA Protein Interactions would be timely. Seven major researchers (six from the USA, one fro m Europe) have already accepted invitations to speak at a Symposium on October 13 15, 1995 in the North Carolina Research Triangle. Funds amounting to almost half the estimated cost of the conference have already been obtained. This proposal requests NSF funding for stipends for one major speaker and three young investigators. The requested funds are approximately 10% of the estimated total budget. %%% RNA synthesis, chemistry, structure and function are central to the viability of all biological systems and thus, are important to agricultural, medical and environmental research. This research has led to biotechnological applications of RNA as both target and reagent. New and exciting RNA structures have been discovered and are revealing interesting new functional modes of interaction with proteins. However, no meetings have focused exclusively on the topic of RNA protein interactions to create an environment of intellectual exchange and a forum to share data and techniques. This proposal funds stipends for one major speaker and three young investigators. *** ; ; @ ....()()))()() Z : phoenix B L s A ; S u m m a r y I n f o r m a t i o n ( 8 Oh +' 0 $ H l D h R:\WWUSER\TEMPLATE\NORMAL.DOT jack cohen jack cohen @ A @ @ 5 @ Microsoft Word 6.0 2 e = e " " " " " " " L L L L L d n L h x | | | | | | | \ r T ( " | | | | | | " " | x | | | | " | " | 6 " " " " | | 0 | 9502254 PRIVATE Agris RNA synthesis, chemistry, structure
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会议论文
Collaborative Research: Sequence Selective Recognition of Double-Stranded Non-Coding RNA via Triplex Forming PNA
  • 批准号:
    1929741
  • 项目类别:
    Standard Grant
  • 资助金额:
    $0.24万
  • 财政年份:
    2018
  • 负责人:
    Paul Agris
  • 依托单位:
Collaborative Research: Sequence Selective Recognition of Double-Stranded Non-Coding RNA via Triplex Forming PNA
  • 批准号:
    1407042
  • 项目类别:
    Standard Grant
  • 资助金额:
    $15.52万
  • 财政年份:
    2014
  • 负责人:
    Paul Agris
  • 依托单位:
Modified Uridines, Contributors of Novel Chemistries to Functional RNA
  • 批准号:
    1101859
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $22.32万
  • 财政年份:
    2010
  • 负责人:
    Paul Agris
  • 依托单位:
Modified Uridines, Contributors of Novel Chemistries to Functional RNA
  • 批准号:
    0548602
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $84.57万
  • 财政年份:
    2006
  • 负责人:
    Paul Agris
  • 依托单位:
国内基金
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