CAREER: Engineering the Behavior of Mammalian Cells Cultured on Elastomeric Substrata

职业：对在弹性体基质上培养的哺乳动物细胞的行为进行工程设计

• 批准号: 9502648
• 负责人: Paul DiMilla
• 金额: $ 21.73万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9502648&HistoricalAwards=false
• 关键词: CAREER; Engineering; Behavior; Mammalian; Cells

9502648 DiMilla This project is on research to study cell-biomaterial interactions. The elements of this research include: (1) the synthesis of polysiloxanes in which the rheological properties will be systematically varied; (2) the further alteration of this media by fibronectin adsorption, or the incorporation of biologically active peptides; (3) the measurement of the motility, morphology, and proliferation of adherent glioblastoma cells on these materials; and (4) the development of a mathematical model to describe the influence of surface mechanical properties on cell behavior. In addition to this research activity, the investigator will enhance education by developing a new course, and eventually a book, on the engineering analysis of cell and tissue systems. ***

9502648迪米拉这个项目正在研究细胞与生物材料之间的相互作用。这项研究的内容包括：(1)聚硅氧烷的合成，其中的流变性将发生系统的变化；(2)通过纤维连接蛋白的吸附或生物活性多肽的加入来进一步改变这种介质；(3)测量贴壁在这些材料上的胶质母细胞瘤细胞的运动性、形态和增殖；以及(4)开发描述表面机械特性对细胞行为影响的数学模型。除了这项研究活动，研究人员还将开发一门关于细胞和组织系统工程分析的新课程，并最终出版一本书，以加强教育。***