Super-Resolution Nanothermometry on Live Cells

活细胞超分辨率纳米测温

• 批准号: FT220100018
• 负责人: Prof Jiajia Zhou
• 金额: $ 67.12万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-06-30 至 2027-06-29
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100018
• 关键词: Super; Resolution; Nanothermometry; Live; Cells

This project aims to deliver new temperature sensors and advance the field of nanothermometry beyond its optical diffraction limit and current reliability issues. The project expects to forge a new way to study organelle metabolism and functional interactions by creating a super-resolution heat map of living cells. Expected outcomes include new knowledge of ionic energy transfer among lanthanide ions, innovative super-resolution imaging nanothermometers, new biochemistry and cell biology protocols, and spectroscopy and microscopy instruments. The adoption of these outcomes in new technologies should provide significant benefits in cell biology research, life sciences, engineering sciences and Australia’s imaging and sensor industries.

该项目旨在提供新的温度传感器，并推动纳米测温领域超越其光学衍射极限和当前的可靠性问题。该项目希望通过创建活细胞的超分辨率热图来建立一种研究细胞器代谢和功能相互作用的新方法。预期成果包括镧系元素离子之间离子能量转移的新知识，创新的超分辨率成像纳米温度计，新的生物化学和细胞生物学协议，以及光谱学和显微镜仪器。在新技术中采用这些成果将为细胞生物学研究、生命科学、工程科学以及澳大利亚的成像和传感器行业带来重大利益。